One-pot synthesis of trifluoromethyl-containing pyrazoles via sequential Yb(PFO)3-catalyzed three-component reaction and IBX-mediated oxidation

Li Shen; Jian Zhang; Song Cao; Jinlong Yu; Nianjin Liu; Jingjing Wu; Xuhong Qian

doi:10.1055/s-0028-1087348

One-pot synthesis of trifluoromethyl-containing pyrazoles via sequential Yb(PFO)₃-catalyzed three-component reaction and IBX-mediated oxidation

Li Shen
, Jian Zhang
, Song Cao^*
, Jinlong Yu
, Nianjin Liu
, Jingjing Wu
, Xuhong Qian

^*Corresponding author for this work

East China University of Science and Technology
CAS - Shanghai Institute of Organic Chemistry

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Fourteen trifluoromethyl-containing fully substituted pyrazoles were synthesized via Yb(PFO)₃-catalyzed three-component condensations of aromatic hydrazines, aldehydes, and ethyl trifluoroacetoacetate, followed by IBX-mediated oxidation of pyrazolones. A possible mechanism is suggested.

Original language	English
Pages (from-to)	3058-3062
Number of pages	5
Journal	Synlett
Issue number	19
DOIs	https://doi.org/10.1055/s-0028-1087348
State	Published - 1 Dec 2008
Externally published	Yes

Keywords

IBX
Three-component synthesis
Trifluoromethyl-containing pyrazole
Yb(PFO)

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10.1055/s-0028-1087348

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title = "One-pot synthesis of trifluoromethyl-containing pyrazoles via sequential Yb(PFO)3-catalyzed three-component reaction and IBX-mediated oxidation",

abstract = "Fourteen trifluoromethyl-containing fully substituted pyrazoles were synthesized via Yb(PFO)3-catalyzed three-component condensations of aromatic hydrazines, aldehydes, and ethyl trifluoroacetoacetate, followed by IBX-mediated oxidation of pyrazolones. A possible mechanism is suggested.",

keywords = "IBX, Three-component synthesis, Trifluoromethyl-containing pyrazole, Yb(PFO)",

author = "Li Shen and Jian Zhang and Song Cao and Jinlong Yu and Nianjin Liu and Jingjing Wu and Xuhong Qian",

year = "2008",

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T1 - One-pot synthesis of trifluoromethyl-containing pyrazoles via sequential Yb(PFO)3-catalyzed three-component reaction and IBX-mediated oxidation

AU - Shen, Li

AU - Zhang, Jian

AU - Cao, Song

AU - Yu, Jinlong

AU - Liu, Nianjin

AU - Wu, Jingjing

AU - Qian, Xuhong

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Fourteen trifluoromethyl-containing fully substituted pyrazoles were synthesized via Yb(PFO)3-catalyzed three-component condensations of aromatic hydrazines, aldehydes, and ethyl trifluoroacetoacetate, followed by IBX-mediated oxidation of pyrazolones. A possible mechanism is suggested.

AB - Fourteen trifluoromethyl-containing fully substituted pyrazoles were synthesized via Yb(PFO)3-catalyzed three-component condensations of aromatic hydrazines, aldehydes, and ethyl trifluoroacetoacetate, followed by IBX-mediated oxidation of pyrazolones. A possible mechanism is suggested.

KW - IBX

KW - Three-component synthesis

KW - Trifluoromethyl-containing pyrazole

KW - Yb(PFO)

UR - https://www.scopus.com/pages/publications/57649126101

U2 - 10.1055/s-0028-1087348

DO - 10.1055/s-0028-1087348

M3 - 文章

AN - SCOPUS:57649126101

SN - 0936-5214

SP - 3058

EP - 3062

JO - Synlett

JF - Synlett

IS - 19

ER -

One-pot synthesis of trifluoromethyl-containing pyrazoles via sequential Yb(PFO)₃-catalyzed three-component reaction and IBX-mediated oxidation

Abstract

Keywords

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