TY - JOUR
T1 - One-Pot Four-Component Assembling for Selenoureas
AU - Li, Lai
AU - Wu, Jiaqi
AU - Wei, Linsha
AU - Lu, Jianmei
AU - Jiang, Xuefeng
N1 - Publisher Copyright:
© 2021 American Chemical Society. All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - An efficient and practical method for the straightforward construction of unsymmetrical selenoureas and cycloselenoureas via the combination of selenium powder, chloroform, and two different amines was comprehensively achieved in one-pot with only the assistance of a base under mild conditions. Thirty-three new structures of unsymmetrical selenoureas including three chiral examples and eight cycloselenoureas were achieved. 1,1-Dimethyl-3-phenylselenourea II, which shows good fungicidal activity, was practically synthesized through this protocol in gram-scale. Isoselenocyanate was further confirmed as a key intermediate by control experiment.
AB - An efficient and practical method for the straightforward construction of unsymmetrical selenoureas and cycloselenoureas via the combination of selenium powder, chloroform, and two different amines was comprehensively achieved in one-pot with only the assistance of a base under mild conditions. Thirty-three new structures of unsymmetrical selenoureas including three chiral examples and eight cycloselenoureas were achieved. 1,1-Dimethyl-3-phenylselenourea II, which shows good fungicidal activity, was practically synthesized through this protocol in gram-scale. Isoselenocyanate was further confirmed as a key intermediate by control experiment.
UR - https://www.scopus.com/pages/publications/85097915228
U2 - 10.1021/acs.joc.0c02179
DO - 10.1021/acs.joc.0c02179
M3 - 文章
AN - SCOPUS:85097915228
SN - 0022-3263
VL - 86
SP - 446
EP - 454
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 1
ER -