Nuclear-Targeting MSNs-Based Drug Delivery System: Global Gene Expression Analysis on the MDR-Overcoming Mechanisms

Xiaoyu Li; Limin Pan; Jianlin Shi

doi:10.1002/adhm.201500548

Nuclear-Targeting MSNs-Based Drug Delivery System: Global Gene Expression Analysis on the MDR-Overcoming Mechanisms

Xiaoyu Li
, Limin Pan
, Jianlin Shi^*

^*Corresponding author for this work

CAS - Shanghai Institute of Ceramics

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The biological mechanisms of nuclear-targeting mesoporous silica nanoparticles (MSNs)-based DDSs (DOX@NT-MSNs) in overcoming multidrug resistance of cancer cells are studied. It is interesting to find for the first time that DOX@NT-MSNs down-regulate the expression of apoptosis suppressor genes and inhibit DNA repair process by disturbing the p53 pathway.

Original language	English
Pages (from-to)	2641-2648
Number of pages	8
Journal	Advanced Healthcare Materials
Volume	4
Issue number	17
DOIs	https://doi.org/10.1002/adhm.201500548
State	Published - 9 Dec 2015
Externally published	Yes

Keywords

Death mechanism
Drug delivery
Gene expression analysis
Multidrug resistance
Nuclear targeted mesoporous silica nanoparticles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adhm.201500548

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title = "Nuclear-Targeting MSNs-Based Drug Delivery System: Global Gene Expression Analysis on the MDR-Overcoming Mechanisms",

abstract = "The biological mechanisms of nuclear-targeting mesoporous silica nanoparticles (MSNs)-based DDSs (DOX@NT-MSNs) in overcoming multidrug resistance of cancer cells are studied. It is interesting to find for the first time that DOX@NT-MSNs down-regulate the expression of apoptosis suppressor genes and inhibit DNA repair process by disturbing the p53 pathway.",

keywords = "Death mechanism, Drug delivery, Gene expression analysis, Multidrug resistance, Nuclear targeted mesoporous silica nanoparticles",

author = "Xiaoyu Li and Limin Pan and Jianlin Shi",

note = "Publisher Copyright: {\textcopyright} 2015 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2015",

month = dec,

day = "9",

doi = "10.1002/adhm.201500548",

language = "英语",

volume = "4",

pages = "2641--2648",

journal = "Advanced Healthcare Materials",

issn = "2192-2640",

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}

TY - JOUR

T1 - Nuclear-Targeting MSNs-Based Drug Delivery System

T2 - Global Gene Expression Analysis on the MDR-Overcoming Mechanisms

AU - Li, Xiaoyu

AU - Pan, Limin

AU - Shi, Jianlin

PY - 2015/12/9

Y1 - 2015/12/9

N2 - The biological mechanisms of nuclear-targeting mesoporous silica nanoparticles (MSNs)-based DDSs (DOX@NT-MSNs) in overcoming multidrug resistance of cancer cells are studied. It is interesting to find for the first time that DOX@NT-MSNs down-regulate the expression of apoptosis suppressor genes and inhibit DNA repair process by disturbing the p53 pathway.

AB - The biological mechanisms of nuclear-targeting mesoporous silica nanoparticles (MSNs)-based DDSs (DOX@NT-MSNs) in overcoming multidrug resistance of cancer cells are studied. It is interesting to find for the first time that DOX@NT-MSNs down-regulate the expression of apoptosis suppressor genes and inhibit DNA repair process by disturbing the p53 pathway.

KW - Death mechanism

KW - Drug delivery

KW - Gene expression analysis

KW - Multidrug resistance

KW - Nuclear targeted mesoporous silica nanoparticles

UR - https://www.scopus.com/pages/publications/84954364160

U2 - 10.1002/adhm.201500548

DO - 10.1002/adhm.201500548

M3 - 文章

C2 - 26450832

AN - SCOPUS:84954364160

SN - 2192-2640

VL - 4

SP - 2641

EP - 2648

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 17

ER -

Nuclear-Targeting MSNs-Based Drug Delivery System: Global Gene Expression Analysis on the MDR-Overcoming Mechanisms

Abstract

Keywords

UN SDGs

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