Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation, side chains, and substituent groups

Zhigang Li; Qing Yang; Xuhong Qian

doi:10.1016/j.bmc.2005.05.006

Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation, side chains, and substituent groups

Zhigang Li
, Qing Yang
, Xuhong Qian^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

A series of novel antitumor and DNA photocleaving agents was designed and synthesized by fusing a (substituted) thiazole ring to the naphthalimide skeletons. C₁, the most active compound against A549, was about 30-fold more cytotoxic than the compound amonafide. A₁, the most active compound against P388, was about 6-fold more cytotoxic than amonafide. C₂, the most efficient DNA intercalator, showed the strongest DNA photocleaving activity via superoxide anion produced under UV light at 360 nm.

Original language	English
Pages (from-to)	4864-4870
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry
Volume	13
Issue number	16
DOIs	https://doi.org/10.1016/j.bmc.2005.05.006
State	Published - 15 Aug 2005
Externally published	Yes

Keywords

Antitumor
Intercalation
Photocleaver
Thiazole

Access to Document

10.1016/j.bmc.2005.05.006

Cite this

@article{47ad0d2825744701a1c884969c441177,

title = "Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation, side chains, and substituent groups",

abstract = "A series of novel antitumor and DNA photocleaving agents was designed and synthesized by fusing a (substituted) thiazole ring to the naphthalimide skeletons. C1, the most active compound against A549, was about 30-fold more cytotoxic than the compound amonafide. A1, the most active compound against P388, was about 6-fold more cytotoxic than amonafide. C2, the most efficient DNA intercalator, showed the strongest DNA photocleaving activity via superoxide anion produced under UV light at 360 nm.",

keywords = "Antitumor, Intercalation, Photocleaver, Thiazole",

author = "Zhigang Li and Qing Yang and Xuhong Qian",

year = "2005",

month = aug,

day = "15",

doi = "10.1016/j.bmc.2005.05.006",

language = "英语",

volume = "13",

pages = "4864--4870",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Ltd",

number = "16",

}

TY - JOUR

T1 - Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents

T2 - Effects of intercalation, side chains, and substituent groups

AU - Li, Zhigang

AU - Yang, Qing

AU - Qian, Xuhong

PY - 2005/8/15

Y1 - 2005/8/15

N2 - A series of novel antitumor and DNA photocleaving agents was designed and synthesized by fusing a (substituted) thiazole ring to the naphthalimide skeletons. C1, the most active compound against A549, was about 30-fold more cytotoxic than the compound amonafide. A1, the most active compound against P388, was about 6-fold more cytotoxic than amonafide. C2, the most efficient DNA intercalator, showed the strongest DNA photocleaving activity via superoxide anion produced under UV light at 360 nm.

AB - A series of novel antitumor and DNA photocleaving agents was designed and synthesized by fusing a (substituted) thiazole ring to the naphthalimide skeletons. C1, the most active compound against A549, was about 30-fold more cytotoxic than the compound amonafide. A1, the most active compound against P388, was about 6-fold more cytotoxic than amonafide. C2, the most efficient DNA intercalator, showed the strongest DNA photocleaving activity via superoxide anion produced under UV light at 360 nm.

KW - Antitumor

KW - Intercalation

KW - Photocleaver

KW - Thiazole

UR - https://www.scopus.com/pages/publications/21744451160

U2 - 10.1016/j.bmc.2005.05.006

DO - 10.1016/j.bmc.2005.05.006

M3 - 文章

C2 - 15925513

AN - SCOPUS:21744451160

SN - 0968-0896

VL - 13

SP - 4864

EP - 4870

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 16

ER -

Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: Effects of intercalation, side chains, and substituent groups

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this