Abstract
Novel perfluoroalkyl phthalocyanine metal derivatives with four perfluorobutyl or four perfluorohexyl groups were synthesized by a two-step procedure starting from 4-iodophthalonitrile; the preparation of the key intermediate 4-(perfluorohexyl)phthalonitrile was optimized. Values of fluorescence quantum yield in ethanol of 0.11 and 0.38 were obtained for zinc(II) tetra (perfluorobutyl)phthalocyanine and zinc(II) tetra (perfluorohexyl) phthalocyanine, respectively. The photodynamic activities of two, zinc (II) phthalocyanine derivatives upon both HL-60 leukemic cells and A375 melanotic cancer cells in vitro were investigated revealed that the cell viability was slightly better in the case of HL-60 than A375.
| Original language | English |
|---|---|
| Pages (from-to) | 127-133 |
| Number of pages | 7 |
| Journal | Dyes and Pigments |
| Volume | 83 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 2009 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- A375 melanotic cancer cell
- HL-60 leukemic cell
- Perfluoroalkyl phthalocyanines
- Photodynamic therapy
- Photosensitizer
- Synthesis
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