Novel perfluoroalkyl phthalocyanine metal derivatives: Synthesis and photodynamic activities

Tao Qiu; Xiaoyong Xu; Jianwen Liu; Xuhong Qian

doi:10.1016/j.dyepig.2009.04.007

Novel perfluoroalkyl phthalocyanine metal derivatives: Synthesis and photodynamic activities

Tao Qiu, Xiaoyong Xu, Jianwen Liu, Xuhong Qian

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Novel perfluoroalkyl phthalocyanine metal derivatives with four perfluorobutyl or four perfluorohexyl groups were synthesized by a two-step procedure starting from 4-iodophthalonitrile; the preparation of the key intermediate 4-(perfluorohexyl)phthalonitrile was optimized. Values of fluorescence quantum yield in ethanol of 0.11 and 0.38 were obtained for zinc(II) tetra (perfluorobutyl)phthalocyanine and zinc(II) tetra (perfluorohexyl) phthalocyanine, respectively. The photodynamic activities of two, zinc (II) phthalocyanine derivatives upon both HL-60 leukemic cells and A375 melanotic cancer cells in vitro were investigated revealed that the cell viability was slightly better in the case of HL-60 than A375.

Original language	English
Pages (from-to)	127-133
Number of pages	7
Journal	Dyes and Pigments
Volume	83
Issue number	1
DOIs	https://doi.org/10.1016/j.dyepig.2009.04.007
State	Published - Oct 2009
Externally published	Yes

Keywords

A375 melanotic cancer cell
HL-60 leukemic cell
Perfluoroalkyl phthalocyanines
Photodynamic therapy
Photosensitizer
Synthesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dyepig.2009.04.007

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title = "Novel perfluoroalkyl phthalocyanine metal derivatives: Synthesis and photodynamic activities",

abstract = "Novel perfluoroalkyl phthalocyanine metal derivatives with four perfluorobutyl or four perfluorohexyl groups were synthesized by a two-step procedure starting from 4-iodophthalonitrile; the preparation of the key intermediate 4-(perfluorohexyl)phthalonitrile was optimized. Values of fluorescence quantum yield in ethanol of 0.11 and 0.38 were obtained for zinc(II) tetra (perfluorobutyl)phthalocyanine and zinc(II) tetra (perfluorohexyl) phthalocyanine, respectively. The photodynamic activities of two, zinc (II) phthalocyanine derivatives upon both HL-60 leukemic cells and A375 melanotic cancer cells in vitro were investigated revealed that the cell viability was slightly better in the case of HL-60 than A375.",

keywords = "A375 melanotic cancer cell, HL-60 leukemic cell, Perfluoroalkyl phthalocyanines, Photodynamic therapy, Photosensitizer, Synthesis",

author = "Tao Qiu and Xiaoyong Xu and Jianwen Liu and Xuhong Qian",

year = "2009",

month = oct,

doi = "10.1016/j.dyepig.2009.04.007",

language = "英语",

volume = "83",

pages = "127--133",

journal = "Dyes and Pigments",

issn = "0143-7208",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Novel perfluoroalkyl phthalocyanine metal derivatives

T2 - Synthesis and photodynamic activities

AU - Qiu, Tao

AU - Xu, Xiaoyong

AU - Liu, Jianwen

AU - Qian, Xuhong

PY - 2009/10

Y1 - 2009/10

N2 - Novel perfluoroalkyl phthalocyanine metal derivatives with four perfluorobutyl or four perfluorohexyl groups were synthesized by a two-step procedure starting from 4-iodophthalonitrile; the preparation of the key intermediate 4-(perfluorohexyl)phthalonitrile was optimized. Values of fluorescence quantum yield in ethanol of 0.11 and 0.38 were obtained for zinc(II) tetra (perfluorobutyl)phthalocyanine and zinc(II) tetra (perfluorohexyl) phthalocyanine, respectively. The photodynamic activities of two, zinc (II) phthalocyanine derivatives upon both HL-60 leukemic cells and A375 melanotic cancer cells in vitro were investigated revealed that the cell viability was slightly better in the case of HL-60 than A375.

AB - Novel perfluoroalkyl phthalocyanine metal derivatives with four perfluorobutyl or four perfluorohexyl groups were synthesized by a two-step procedure starting from 4-iodophthalonitrile; the preparation of the key intermediate 4-(perfluorohexyl)phthalonitrile was optimized. Values of fluorescence quantum yield in ethanol of 0.11 and 0.38 were obtained for zinc(II) tetra (perfluorobutyl)phthalocyanine and zinc(II) tetra (perfluorohexyl) phthalocyanine, respectively. The photodynamic activities of two, zinc (II) phthalocyanine derivatives upon both HL-60 leukemic cells and A375 melanotic cancer cells in vitro were investigated revealed that the cell viability was slightly better in the case of HL-60 than A375.

KW - A375 melanotic cancer cell

KW - HL-60 leukemic cell

KW - Perfluoroalkyl phthalocyanines

KW - Photodynamic therapy

KW - Photosensitizer

KW - Synthesis

UR - https://www.scopus.com/pages/publications/66049120954

U2 - 10.1016/j.dyepig.2009.04.007

DO - 10.1016/j.dyepig.2009.04.007

M3 - 文章

AN - SCOPUS:66049120954

SN - 0143-7208

VL - 83

SP - 127

EP - 133

JO - Dyes and Pigments

JF - Dyes and Pigments

IS - 1

ER -

Novel perfluoroalkyl phthalocyanine metal derivatives: Synthesis and photodynamic activities

Abstract

Keywords

UN SDGs

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