TY - JOUR
T1 - Novel naphthalimide hydroperoxide photonucleases
T2 - The role of thiocyclic-Fused area and the difference in spectra, photochemistry and photobiological activity
AU - Xu, Yufang
AU - Qian, Xuhong
AU - Yao, Wei
AU - Mao, Ping
AU - Cui, Jingnan
PY - 2003/12/1
Y1 - 2003/12/1
N2 - Novel five- and six-membered thiocyclic-fused naphthalimide hydroperoxides (7, 8) as photonucleases were designed, synthesized via unusual isomerization in Pschorr cyclization and photooxygenation. The five-membered 7 was able to induce single-strand nicks in duplex DNA pH independently (7.0-8.5) at 0.5 μM under 366 nm, while the six-membered 8 could photonick the duplex DNA pH dependently (7.0-8.5) at 5 μM under 450 nm and showed 'time-controlled' photo-bioactivity. Their thiocycles and the angular conjugated plane have contributions to their binding affinity with DNA and photocleaving efficiency.
AB - Novel five- and six-membered thiocyclic-fused naphthalimide hydroperoxides (7, 8) as photonucleases were designed, synthesized via unusual isomerization in Pschorr cyclization and photooxygenation. The five-membered 7 was able to induce single-strand nicks in duplex DNA pH independently (7.0-8.5) at 0.5 μM under 366 nm, while the six-membered 8 could photonick the duplex DNA pH dependently (7.0-8.5) at 5 μM under 450 nm and showed 'time-controlled' photo-bioactivity. Their thiocycles and the angular conjugated plane have contributions to their binding affinity with DNA and photocleaving efficiency.
UR - https://www.scopus.com/pages/publications/0345714633
U2 - 10.1016/j.bmc.2003.09.026
DO - 10.1016/j.bmc.2003.09.026
M3 - 文章
C2 - 14642587
AN - SCOPUS:0345714633
SN - 0968-0896
VL - 11
SP - 5427
EP - 5433
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 24
ER -