Novel inhibitors for p90 ribosomal S6 protein kinase 2: Design, synthesis and SAR

Mengzhu Xue; Jun Yuan; Bin Wu; Xue Zhao; Xiaofeng Liu; Jin Huang; Zhenjiang Zhao; Honglin Li; Yufang Xu

doi:10.5246/jcps.2012.05.053

Novel inhibitors for p90 ribosomal S6 protein kinase 2: Design, synthesis and SAR

Mengzhu Xue, Jun Yuan, Bin Wu, Xue Zhao, Xiaofeng Liu, Jin Huang, Zhenjiang Zhao, Honglin Li, Yufang Xu

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A series of benzohydrazide derivatives as novel ribosomal S6 kinase 2 (RSK2) inhibitors were designed and synthesized from a hit compound previously discovered by ligandbased virtual screening. Biological assays showed that these compounds possessed moderate inhibitory activities towards RSK2. The structural activity relationships (SAR) were elucidated by molecular docking and further optimization was performed.

Original language	English
Pages (from-to)	401-408
Number of pages	8
Journal	Journal of Chinese Pharmaceutical Sciences
Volume	21
Issue number	5
DOIs	https://doi.org/10.5246/jcps.2012.05.053
State	Published - 2012
Externally published	Yes

Keywords

Benzohydrazide derivatives
Molecular docking
RSK2 inhibitors
SAR

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10.5246/jcps.2012.05.053

Cite this

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title = "Novel inhibitors for p90 ribosomal S6 protein kinase 2: Design, synthesis and SAR",

abstract = "A series of benzohydrazide derivatives as novel ribosomal S6 kinase 2 (RSK2) inhibitors were designed and synthesized from a hit compound previously discovered by ligandbased virtual screening. Biological assays showed that these compounds possessed moderate inhibitory activities towards RSK2. The structural activity relationships (SAR) were elucidated by molecular docking and further optimization was performed.",

keywords = "Benzohydrazide derivatives, Molecular docking, RSK2 inhibitors, SAR",

author = "Mengzhu Xue and Jun Yuan and Bin Wu and Xue Zhao and Xiaofeng Liu and Jin Huang and Zhenjiang Zhao and Honglin Li and Yufang Xu",

year = "2012",

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T1 - Novel inhibitors for p90 ribosomal S6 protein kinase 2

T2 - Design, synthesis and SAR

AU - Xue, Mengzhu

AU - Yuan, Jun

AU - Wu, Bin

AU - Zhao, Xue

AU - Liu, Xiaofeng

AU - Huang, Jin

AU - Zhao, Zhenjiang

AU - Li, Honglin

AU - Xu, Yufang

PY - 2012

Y1 - 2012

N2 - A series of benzohydrazide derivatives as novel ribosomal S6 kinase 2 (RSK2) inhibitors were designed and synthesized from a hit compound previously discovered by ligandbased virtual screening. Biological assays showed that these compounds possessed moderate inhibitory activities towards RSK2. The structural activity relationships (SAR) were elucidated by molecular docking and further optimization was performed.

AB - A series of benzohydrazide derivatives as novel ribosomal S6 kinase 2 (RSK2) inhibitors were designed and synthesized from a hit compound previously discovered by ligandbased virtual screening. Biological assays showed that these compounds possessed moderate inhibitory activities towards RSK2. The structural activity relationships (SAR) were elucidated by molecular docking and further optimization was performed.

KW - Benzohydrazide derivatives

KW - Molecular docking

KW - RSK2 inhibitors

KW - SAR

UR - https://www.scopus.com/pages/publications/84872256505

U2 - 10.5246/jcps.2012.05.053

DO - 10.5246/jcps.2012.05.053

M3 - 文章

AN - SCOPUS:84872256505

SN - 1003-1057

VL - 21

SP - 401

EP - 408

JO - Journal of Chinese Pharmaceutical Sciences

JF - Journal of Chinese Pharmaceutical Sciences

IS - 5

ER -

Novel inhibitors for p90 ribosomal S6 protein kinase 2: Design, synthesis and SAR

Abstract

Keywords

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