TY - JOUR
T1 - Novel indole α-methylene-γ-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases
AU - Ding, Huasheng
AU - Zhang, Chao
AU - Wu, Xihan
AU - Yang, Chunhao
AU - Zhang, Xiongwen
AU - Ding, Jian
AU - Xie, Yuyuan
PY - 2005/11/1
Y1 - 2005/11/1
N2 - In an effort to generate novel anticancer agents, a series of hybrids of α-methylene-γ-lactones and 2-phenyl indoles has been synthesized and evaluated for inhibition activities on the phosphorylation of AKT, mTOR, p70S6 kinase, and 4E-BP1. The results indicate that substitutes on the γ-position of lactones have a rather significant influence on inhibition activities.
AB - In an effort to generate novel anticancer agents, a series of hybrids of α-methylene-γ-lactones and 2-phenyl indoles has been synthesized and evaluated for inhibition activities on the phosphorylation of AKT, mTOR, p70S6 kinase, and 4E-BP1. The results indicate that substitutes on the γ-position of lactones have a rather significant influence on inhibition activities.
KW - AKT-mTOR signaling pathway kinase
KW - Indole α-methylene-γ-lactones
KW - Inhibitors
UR - https://www.scopus.com/pages/publications/25144514550
U2 - 10.1016/j.bmcl.2005.07.050
DO - 10.1016/j.bmcl.2005.07.050
M3 - 文章
C2 - 16143526
AN - SCOPUS:25144514550
SN - 0960-894X
VL - 15
SP - 4799
EP - 4802
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 21
ER -