Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding

Yan Liu; Yufang Xu; Xuhong Qian; Jianwen Liu; Liyun Shen; Junhui Li; Yuanxing Zhang

doi:10.1016/j.bmc.2005.12.012

Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding

Yan Liu, Yufang Xu, Xuhong Qian, Jianwen Liu, Liyun Shen, Junhui Li, Yuanxing Zhang

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Novel naphthalimides with two heterocyclic side chains of 2-nitroimidazole for bioreductive binding were designed, synthesized, and used as fluorescent markers for hypoxic cells. Their evaluation for imaging tumor hypoxia was carried out in V79 cells, CHO cells, and 95D cells in vitro by using fluorescence scan ascent. A₂ and A₄ showed a very large differential fluorescence between hypoxic and oxic cells (V79 cells) in vitro and are promising candidate markers for hypoxic cells.

Original language	English
Pages (from-to)	2935-2941
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry
Volume	14
Issue number	9
DOIs	https://doi.org/10.1016/j.bmc.2005.12.012
State	Published - 1 May 2006
Externally published	Yes

Keywords

2-Nitroimidazole
Bioreductive binding
Fluorescent markers
Hypoxic cells
Naphthalimides

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10.1016/j.bmc.2005.12.012

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title = "Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding",

abstract = "Novel naphthalimides with two heterocyclic side chains of 2-nitroimidazole for bioreductive binding were designed, synthesized, and used as fluorescent markers for hypoxic cells. Their evaluation for imaging tumor hypoxia was carried out in V79 cells, CHO cells, and 95D cells in vitro by using fluorescence scan ascent. A2 and A4 showed a very large differential fluorescence between hypoxic and oxic cells (V79 cells) in vitro and are promising candidate markers for hypoxic cells.",

keywords = "2-Nitroimidazole, Bioreductive binding, Fluorescent markers, Hypoxic cells, Naphthalimides",

author = "Yan Liu and Yufang Xu and Xuhong Qian and Jianwen Liu and Liyun Shen and Junhui Li and Yuanxing Zhang",

year = "2006",

month = may,

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doi = "10.1016/j.bmc.2005.12.012",

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journal = "Bioorganic and Medicinal Chemistry",

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T1 - Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding

AU - Liu, Yan

AU - Xu, Yufang

AU - Qian, Xuhong

AU - Liu, Jianwen

AU - Shen, Liyun

AU - Li, Junhui

AU - Zhang, Yuanxing

PY - 2006/5/1

Y1 - 2006/5/1

N2 - Novel naphthalimides with two heterocyclic side chains of 2-nitroimidazole for bioreductive binding were designed, synthesized, and used as fluorescent markers for hypoxic cells. Their evaluation for imaging tumor hypoxia was carried out in V79 cells, CHO cells, and 95D cells in vitro by using fluorescence scan ascent. A2 and A4 showed a very large differential fluorescence between hypoxic and oxic cells (V79 cells) in vitro and are promising candidate markers for hypoxic cells.

AB - Novel naphthalimides with two heterocyclic side chains of 2-nitroimidazole for bioreductive binding were designed, synthesized, and used as fluorescent markers for hypoxic cells. Their evaluation for imaging tumor hypoxia was carried out in V79 cells, CHO cells, and 95D cells in vitro by using fluorescence scan ascent. A2 and A4 showed a very large differential fluorescence between hypoxic and oxic cells (V79 cells) in vitro and are promising candidate markers for hypoxic cells.

KW - 2-Nitroimidazole

KW - Bioreductive binding

KW - Fluorescent markers

KW - Hypoxic cells

KW - Naphthalimides

UR - https://www.scopus.com/pages/publications/33644983345

U2 - 10.1016/j.bmc.2005.12.012

DO - 10.1016/j.bmc.2005.12.012

M3 - 文章

C2 - 16403640

AN - SCOPUS:33644983345

SN - 0968-0896

VL - 14

SP - 2935

EP - 2941

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 9

ER -

Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding

Abstract

Keywords

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