Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor

Hong Yin; Weiping Zhu; Yufang Xu; Min Dai; Xuhong Qian; Yuanli Li; Jianwen Liu

doi:10.1016/j.ejmech.2011.04.040

Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor

Hong Yin
, Weiping Zhu
, Yufang Xu^*
, Min Dai
, Xuhong Qian
, Yuanli Li
, Jianwen Liu

^*Corresponding author for this work

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A series of novel aliphatic N-oxide of naphthalimides (A1-A5) were designed and prepared. The N-O group was firstly introduced into the amine side chain tailed to planar naphthalimide chromophore as hypoxic bioreductive marker. Fluorescence image analysis showed that the compounds could be used as potential markers for hypoxic cells (V79) in vitro especially for A1 with 17 times hypoxic-oxic fluorescence differential, which was probably due to the bis-bioreduction mechanism.

Original language	English
Pages (from-to)	3030-3037
Number of pages	8
Journal	European Journal of Medicinal Chemistry
Volume	46
Issue number	7
DOIs	https://doi.org/10.1016/j.ejmech.2011.04.040
State	Published - Jul 2011
Externally published	Yes

Keywords

Bioreduction
Fluorescent marker
Hypoxic
N-Oxide
Naphthalimide

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10.1016/j.ejmech.2011.04.040

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title = "Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor",

abstract = "A series of novel aliphatic N-oxide of naphthalimides (A1-A5) were designed and prepared. The N-O group was firstly introduced into the amine side chain tailed to planar naphthalimide chromophore as hypoxic bioreductive marker. Fluorescence image analysis showed that the compounds could be used as potential markers for hypoxic cells (V79) in vitro especially for A1 with 17 times hypoxic-oxic fluorescence differential, which was probably due to the bis-bioreduction mechanism.",

keywords = "Bioreduction, Fluorescent marker, Hypoxic, N-Oxide, Naphthalimide",

author = "Hong Yin and Weiping Zhu and Yufang Xu and Min Dai and Xuhong Qian and Yuanli Li and Jianwen Liu",

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AU - Yin, Hong

AU - Zhu, Weiping

AU - Xu, Yufang

AU - Dai, Min

AU - Qian, Xuhong

AU - Li, Yuanli

AU - Liu, Jianwen

PY - 2011/7

Y1 - 2011/7

N2 - A series of novel aliphatic N-oxide of naphthalimides (A1-A5) were designed and prepared. The N-O group was firstly introduced into the amine side chain tailed to planar naphthalimide chromophore as hypoxic bioreductive marker. Fluorescence image analysis showed that the compounds could be used as potential markers for hypoxic cells (V79) in vitro especially for A1 with 17 times hypoxic-oxic fluorescence differential, which was probably due to the bis-bioreduction mechanism.

AB - A series of novel aliphatic N-oxide of naphthalimides (A1-A5) were designed and prepared. The N-O group was firstly introduced into the amine side chain tailed to planar naphthalimide chromophore as hypoxic bioreductive marker. Fluorescence image analysis showed that the compounds could be used as potential markers for hypoxic cells (V79) in vitro especially for A1 with 17 times hypoxic-oxic fluorescence differential, which was probably due to the bis-bioreduction mechanism.

KW - Bioreduction

KW - Fluorescent marker

KW - Hypoxic

KW - N-Oxide

KW - Naphthalimide

UR - https://www.scopus.com/pages/publications/79957454838

U2 - 10.1016/j.ejmech.2011.04.040

DO - 10.1016/j.ejmech.2011.04.040

M3 - 文章

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AN - SCOPUS:79957454838

SN - 0223-5234

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SP - 3030

EP - 3037

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 7

ER -

Novel aliphatic N-oxide of naphthalimides as fluorescent markers for hypoxic cells in solid tumor

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Keywords

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