Non-alcoholic fatty liver disease: A starting point of the onset of type 2 diabetes mellitus?

Jianping Weng; Yan Bi; Dalong Zhu; Youfei Guan

doi:10.3969/j.issn.0253-2778.2018.10.001

Non-alcoholic fatty liver disease: A starting point of the onset of type 2 diabetes mellitus?

Jianping Weng^*
, Yan Bi
, Dalong Zhu
, Youfei Guan

^*Corresponding author for this work

University of Science and Technology of China
Nanjing University
Dalian Medical University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

With changes in lifestyle, non-alcoholic fatly liver disease (NAFLD) has become the most common liver disease. As metabolic diseases, NAFLD is strongly associated with type 2 diabetes mellitus (T2DM). An individual’s risk of developing diabetes is increased approximately 5-fold if they have NAFLD. Numerous studies suggest that NAFLD has a causal role in the onset of T2DM. Therefore, unraveling the relationship between lipid metabolism disturbance and T2DM contributes to the understanding of the etiology of T2DM and the intervention of T2DM.This paper reviewed the mechanisms underlying the pathogenesis of T2DM by NAFLD such as insulin resistance, increased inflammatory mediator release, induction of metabolic dysfunction by hepatokines, impaired (3-cell function, influence on incretin by liver and decreased insulin sensitivity in adipose tissue.

Original language	English
Article number	0253-2778(2018)10-0777-04
Pages (from-to)	777-780
Number of pages	4
Journal	Journal of University of Science and Technology of China
Volume	48
Issue number	10
DOIs	https://doi.org/10.3969/j.issn.0253-2778.2018.10.001
State	Published - Oct 2018
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Glucagon-like peptide-1
Inflammation
Insulin resistance
Lipid metabolism
Non-alcoholic fatty liver disease
Type 2 diabetes mellitus
β-cell function

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10.3969/j.issn.0253-2778.2018.10.001

Cite this

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title = "Non-alcoholic fatty liver disease: A starting point of the onset of type 2 diabetes mellitus?",

abstract = "With changes in lifestyle, non-alcoholic fatly liver disease (NAFLD) has become the most common liver disease. As metabolic diseases, NAFLD is strongly associated with type 2 diabetes mellitus (T2DM). An individual{\textquoteright}s risk of developing diabetes is increased approximately 5-fold if they have NAFLD. Numerous studies suggest that NAFLD has a causal role in the onset of T2DM. Therefore, unraveling the relationship between lipid metabolism disturbance and T2DM contributes to the understanding of the etiology of T2DM and the intervention of T2DM.This paper reviewed the mechanisms underlying the pathogenesis of T2DM by NAFLD such as insulin resistance, increased inflammatory mediator release, induction of metabolic dysfunction by hepatokines, impaired (3-cell function, influence on incretin by liver and decreased insulin sensitivity in adipose tissue.",

keywords = "Glucagon-like peptide-1, Inflammation, Insulin resistance, Lipid metabolism, Non-alcoholic fatty liver disease, Type 2 diabetes mellitus, β-cell function",

author = "Jianping Weng and Yan Bi and Dalong Zhu and Youfei Guan",

year = "2018",

month = oct,

doi = "10.3969/j.issn.0253-2778.2018.10.001",

language = "英语",

volume = "48",

pages = "777--780",

journal = "Journal of University of Science and Technology of China",

issn = "0253-2778",

publisher = "China University of Science and Technology",

number = "10",

}

TY - JOUR

T1 - Non-alcoholic fatty liver disease

T2 - A starting point of the onset of type 2 diabetes mellitus?

AU - Weng, Jianping

AU - Bi, Yan

AU - Zhu, Dalong

AU - Guan, Youfei

PY - 2018/10

Y1 - 2018/10

N2 - With changes in lifestyle, non-alcoholic fatly liver disease (NAFLD) has become the most common liver disease. As metabolic diseases, NAFLD is strongly associated with type 2 diabetes mellitus (T2DM). An individual’s risk of developing diabetes is increased approximately 5-fold if they have NAFLD. Numerous studies suggest that NAFLD has a causal role in the onset of T2DM. Therefore, unraveling the relationship between lipid metabolism disturbance and T2DM contributes to the understanding of the etiology of T2DM and the intervention of T2DM.This paper reviewed the mechanisms underlying the pathogenesis of T2DM by NAFLD such as insulin resistance, increased inflammatory mediator release, induction of metabolic dysfunction by hepatokines, impaired (3-cell function, influence on incretin by liver and decreased insulin sensitivity in adipose tissue.

AB - With changes in lifestyle, non-alcoholic fatly liver disease (NAFLD) has become the most common liver disease. As metabolic diseases, NAFLD is strongly associated with type 2 diabetes mellitus (T2DM). An individual’s risk of developing diabetes is increased approximately 5-fold if they have NAFLD. Numerous studies suggest that NAFLD has a causal role in the onset of T2DM. Therefore, unraveling the relationship between lipid metabolism disturbance and T2DM contributes to the understanding of the etiology of T2DM and the intervention of T2DM.This paper reviewed the mechanisms underlying the pathogenesis of T2DM by NAFLD such as insulin resistance, increased inflammatory mediator release, induction of metabolic dysfunction by hepatokines, impaired (3-cell function, influence on incretin by liver and decreased insulin sensitivity in adipose tissue.

KW - Glucagon-like peptide-1

KW - Inflammation

KW - Insulin resistance

KW - Lipid metabolism

KW - Non-alcoholic fatty liver disease

KW - Type 2 diabetes mellitus

KW - β-cell function

UR - https://www.scopus.com/pages/publications/85065991995

U2 - 10.3969/j.issn.0253-2778.2018.10.001

DO - 10.3969/j.issn.0253-2778.2018.10.001

M3 - 文章

AN - SCOPUS:85065991995

SN - 0253-2778

VL - 48

SP - 777

EP - 780

JO - Journal of University of Science and Technology of China

JF - Journal of University of Science and Technology of China

IS - 10

M1 - 0253-2778(2018)10-0777-04

ER -

Non-alcoholic fatty liver disease: A starting point of the onset of type 2 diabetes mellitus?

Abstract

UN SDGs

Keywords

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