TY - JOUR
T1 - Non-alcoholic fatty liver disease
T2 - A starting point of the onset of type 2 diabetes mellitus?
AU - Weng, Jianping
AU - Bi, Yan
AU - Zhu, Dalong
AU - Guan, Youfei
N1 - Publisher Copyright:
© 2018, Editorial Department of Journal of University of Science and Technology of China. All rights reserved.
PY - 2018/10
Y1 - 2018/10
N2 - With changes in lifestyle, non-alcoholic fatly liver disease (NAFLD) has become the most common liver disease. As metabolic diseases, NAFLD is strongly associated with type 2 diabetes mellitus (T2DM). An individual’s risk of developing diabetes is increased approximately 5-fold if they have NAFLD. Numerous studies suggest that NAFLD has a causal role in the onset of T2DM. Therefore, unraveling the relationship between lipid metabolism disturbance and T2DM contributes to the understanding of the etiology of T2DM and the intervention of T2DM.This paper reviewed the mechanisms underlying the pathogenesis of T2DM by NAFLD such as insulin resistance, increased inflammatory mediator release, induction of metabolic dysfunction by hepatokines, impaired (3-cell function, influence on incretin by liver and decreased insulin sensitivity in adipose tissue.
AB - With changes in lifestyle, non-alcoholic fatly liver disease (NAFLD) has become the most common liver disease. As metabolic diseases, NAFLD is strongly associated with type 2 diabetes mellitus (T2DM). An individual’s risk of developing diabetes is increased approximately 5-fold if they have NAFLD. Numerous studies suggest that NAFLD has a causal role in the onset of T2DM. Therefore, unraveling the relationship between lipid metabolism disturbance and T2DM contributes to the understanding of the etiology of T2DM and the intervention of T2DM.This paper reviewed the mechanisms underlying the pathogenesis of T2DM by NAFLD such as insulin resistance, increased inflammatory mediator release, induction of metabolic dysfunction by hepatokines, impaired (3-cell function, influence on incretin by liver and decreased insulin sensitivity in adipose tissue.
KW - Glucagon-like peptide-1
KW - Inflammation
KW - Insulin resistance
KW - Lipid metabolism
KW - Non-alcoholic fatty liver disease
KW - Type 2 diabetes mellitus
KW - β-cell function
UR - https://www.scopus.com/pages/publications/85065991995
U2 - 10.3969/j.issn.0253-2778.2018.10.001
DO - 10.3969/j.issn.0253-2778.2018.10.001
M3 - 文章
AN - SCOPUS:85065991995
SN - 0253-2778
VL - 48
SP - 777
EP - 780
JO - Journal of University of Science and Technology of China
JF - Journal of University of Science and Technology of China
IS - 10
M1 - 0253-2778(2018)10-0777-04
ER -
