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NIR-triggered anticancer drug delivery by upconverting nanoparticles with integrated azobenzene-modified mesoporous silica

  • Jianan Liu*
  • , Wenbo Bu
  • , Limin Pan
  • , Jianlin Shi
  • *Corresponding author for this work
  • CAS - Shanghai Institute of Ceramics

Research output: Contribution to journalArticlepeer-review

Abstract

Photomediated drug release: Silica-coated upconverting nanoparticles with mesopores modified by azobenzene molecules were synthesized. The azobenzene molecules make possible the release of the anticancer drug doxorubicin from the pore network of the mesoporous silica outer layer by irradiation with near-infrared (NIR) laser light. The release is regulated by the trans-cis photoisomerization of the azobenzene molecules (see picture).

Original languageEnglish
Pages (from-to)4375-4379
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number16
DOIs
StatePublished - 15 Apr 2013
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • cancer
  • drug delivery
  • mesoporous materials
  • upconverting nanoparticles

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