NIR absorbing DICPO derivatives applied to wide range of pH and detection of glutathione in tumor

Bin Bao; Meng Liu; Yaqian Liu; Xuan Zhang; Yi Zang; Jia Li; Wei Lu

doi:10.1016/j.tet.2015.08.020

NIR absorbing DICPO derivatives applied to wide range of pH and detection of glutathione in tumor

Bin Bao, Meng Liu, Yaqian Liu, Xuan Zhang, Yi Zang, Jia Li, Wei Lu^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

New DPCO derivatives were developed for application at a wide range of pH values. Cl-DPCO exhibited better optical properties than DPCO in solutions with pH values from 5.0 to 9.0 and was preferable for the design of probes, especially for the imaging of a tumor micro-environment which is acidic. With Cl-DPCO probe 1 was designed for the detection of GSH. Probe 1 was sensitive to GSH in environments at pH values of 5.7 and 7.4, and strong near-infrared fluorescence was detected. Moreover, probe 1 had good response to the endogenous GSH in living cells, which suggested that Cl-DPCO has potential in the design of other tumor-associated probes.

Original language	English
Pages (from-to)	7865-7868
Number of pages	4
Journal	Tetrahedron
Volume	71
Issue number	41
DOIs	https://doi.org/10.1016/j.tet.2015.08.020
State	Published - 14 Oct 2015

Keywords

DICPO
GSH
NIR
pH

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10.1016/j.tet.2015.08.020

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title = "NIR absorbing DICPO derivatives applied to wide range of pH and detection of glutathione in tumor",

abstract = "New DPCO derivatives were developed for application at a wide range of pH values. Cl-DPCO exhibited better optical properties than DPCO in solutions with pH values from 5.0 to 9.0 and was preferable for the design of probes, especially for the imaging of a tumor micro-environment which is acidic. With Cl-DPCO probe 1 was designed for the detection of GSH. Probe 1 was sensitive to GSH in environments at pH values of 5.7 and 7.4, and strong near-infrared fluorescence was detected. Moreover, probe 1 had good response to the endogenous GSH in living cells, which suggested that Cl-DPCO has potential in the design of other tumor-associated probes.",

keywords = "DICPO, GSH, NIR, pH",

author = "Bin Bao and Meng Liu and Yaqian Liu and Xuan Zhang and Yi Zang and Jia Li and Wei Lu",

year = "2015",

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T1 - NIR absorbing DICPO derivatives applied to wide range of pH and detection of glutathione in tumor

AU - Bao, Bin

AU - Liu, Meng

AU - Liu, Yaqian

AU - Zhang, Xuan

AU - Zang, Yi

AU - Li, Jia

AU - Lu, Wei

PY - 2015/10/14

Y1 - 2015/10/14

N2 - New DPCO derivatives were developed for application at a wide range of pH values. Cl-DPCO exhibited better optical properties than DPCO in solutions with pH values from 5.0 to 9.0 and was preferable for the design of probes, especially for the imaging of a tumor micro-environment which is acidic. With Cl-DPCO probe 1 was designed for the detection of GSH. Probe 1 was sensitive to GSH in environments at pH values of 5.7 and 7.4, and strong near-infrared fluorescence was detected. Moreover, probe 1 had good response to the endogenous GSH in living cells, which suggested that Cl-DPCO has potential in the design of other tumor-associated probes.

AB - New DPCO derivatives were developed for application at a wide range of pH values. Cl-DPCO exhibited better optical properties than DPCO in solutions with pH values from 5.0 to 9.0 and was preferable for the design of probes, especially for the imaging of a tumor micro-environment which is acidic. With Cl-DPCO probe 1 was designed for the detection of GSH. Probe 1 was sensitive to GSH in environments at pH values of 5.7 and 7.4, and strong near-infrared fluorescence was detected. Moreover, probe 1 had good response to the endogenous GSH in living cells, which suggested that Cl-DPCO has potential in the design of other tumor-associated probes.

KW - DICPO

KW - GSH

KW - NIR

KW - pH

UR - https://www.scopus.com/pages/publications/84940793050

U2 - 10.1016/j.tet.2015.08.020

DO - 10.1016/j.tet.2015.08.020

M3 - 文章

AN - SCOPUS:84940793050

SN - 0040-4020

VL - 71

SP - 7865

EP - 7868

JO - Tetrahedron

JF - Tetrahedron

IS - 41

ER -

NIR absorbing DICPO derivatives applied to wide range of pH and detection of glutathione in tumor

Abstract

Keywords

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