Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of: N -(2-iodo-aryl) acrylamide

Guangzhu Wang; Chaoren Shen; Xinyi Ren; Kaiwu Dong

doi:10.1039/d1cc04996h

Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of: N -(2-iodo-aryl) acrylamide

Guangzhu Wang
, Chaoren Shen
, Xinyi Ren
, Kaiwu Dong

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A Ni/(S,S)-BDPP-catalyzed intramolecular Heck cyclization of N-(2-iodo-aryl) acrylamide with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. We found that utilizing such an electrophilic cyanation reagent could tackle the deleterious effect of the coordinative cyanide ion in the asymmetric alkene arylcyanation.

Original language	English
Pages (from-to)	1135-1138
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	8
DOIs	https://doi.org/10.1039/d1cc04996h
State	Published - 25 Jan 2022

Access to Document

10.1039/d1cc04996h

Cite this

@article{976a3d1472f9456fbf2cbcdb17286d44,

title = "Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of: N -(2-iodo-aryl) acrylamide",

abstract = "A Ni/(S,S)-BDPP-catalyzed intramolecular Heck cyclization of N-(2-iodo-aryl) acrylamide with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. We found that utilizing such an electrophilic cyanation reagent could tackle the deleterious effect of the coordinative cyanide ion in the asymmetric alkene arylcyanation.",

author = "Guangzhu Wang and Chaoren Shen and Xinyi Ren and Kaiwu Dong",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2022",

month = jan,

day = "25",

doi = "10.1039/d1cc04996h",

language = "英语",

volume = "58",

pages = "1135--1138",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "8",

}

TY - JOUR

T1 - Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of

T2 - N -(2-iodo-aryl) acrylamide

AU - Wang, Guangzhu

AU - Shen, Chaoren

AU - Ren, Xinyi

AU - Dong, Kaiwu

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2022/1/25

Y1 - 2022/1/25

N2 - A Ni/(S,S)-BDPP-catalyzed intramolecular Heck cyclization of N-(2-iodo-aryl) acrylamide with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. We found that utilizing such an electrophilic cyanation reagent could tackle the deleterious effect of the coordinative cyanide ion in the asymmetric alkene arylcyanation.

AB - A Ni/(S,S)-BDPP-catalyzed intramolecular Heck cyclization of N-(2-iodo-aryl) acrylamide with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. We found that utilizing such an electrophilic cyanation reagent could tackle the deleterious effect of the coordinative cyanide ion in the asymmetric alkene arylcyanation.

UR - https://www.scopus.com/pages/publications/85123791534

U2 - 10.1039/d1cc04996h

DO - 10.1039/d1cc04996h

M3 - 文章

C2 - 34981092

AN - SCOPUS:85123791534

SN - 1359-7345

VL - 58

SP - 1135

EP - 1138

JO - Chemical Communications

JF - Chemical Communications

IS - 8

ER -

Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of: N -(2-iodo-aryl) acrylamide

Abstract

Access to Document

Other files and links

Fingerprint

Cite this