New method of PE gylated chemical medicine

Chun Mei Song; Xiao Lu Zhuang; Mei Ran Xie; Yi Qun Zhang

New method of PE gylated chemical medicine

Chun Mei Song^*
, Xiao Lu Zhuang
, Mei Ran Xie
, Yi Qun Zhang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In this paper, nicotinic acid, benzoic acid and p-nitrobenzoic applied in clinical were used as the model drugs. Small molecular drugs with carboxyl were PEGylated via degradable ester bonds by two-step process. The yield of products were 80%-85%. The small molecular drugs will be released by the degradation of ester bonds. The macromolecular prodrugs were characterized by IR, ¹H-NMR and DSC. The results suggeste that small molecular drugs are conjugated to PEG. Products are dissolvable in most organic solvents such as CH₂Cl₂, THF, CH₃CH₂OH., CHCl₃, CH₃COCH₃, DMF., DMSO. The solubility of the products has been improved in aqueous solutions. The example of PEG-(nicotinic acid)₂ had been discussed detailedly.

Original language	English
Pages (from-to)	143-146
Number of pages	4
Journal	Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering
Volume	24
Issue number	1
State	Published - Jan 2008

Keywords

Modification
Nicotinic acid
Polyethylene glycol
Small molecule drugs
Two-step process

Cite this

@article{c51f4317c5ba4578ae623197220b0f00,

title = "New method of PE gylated chemical medicine",

abstract = "In this paper, nicotinic acid, benzoic acid and p-nitrobenzoic applied in clinical were used as the model drugs. Small molecular drugs with carboxyl were PEGylated via degradable ester bonds by two-step process. The yield of products were 80\%-85\%. The small molecular drugs will be released by the degradation of ester bonds. The macromolecular prodrugs were characterized by IR, 1H-NMR and DSC. The results suggeste that small molecular drugs are conjugated to PEG. Products are dissolvable in most organic solvents such as CH2Cl2, THF, CH3CH2OH., CHCl3, CH3COCH3, DMF., DMSO. The solubility of the products has been improved in aqueous solutions. The example of PEG-(nicotinic acid)2 had been discussed detailedly.",

keywords = "Modification, Nicotinic acid, Polyethylene glycol, Small molecule drugs, Two-step process",

author = "Song, \{Chun Mei\} and Zhuang, \{Xiao Lu\} and Xie, \{Mei Ran\} and Zhang, \{Yi Qun\}",

year = "2008",

month = jan,

language = "英语",

volume = "24",

pages = "143--146",

journal = "Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering",

issn = "1000-7555",

publisher = "Chengdu University of Science and Technology",

number = "1",

}

TY - JOUR

T1 - New method of PE gylated chemical medicine

AU - Song, Chun Mei

AU - Zhuang, Xiao Lu

AU - Xie, Mei Ran

AU - Zhang, Yi Qun

PY - 2008/1

Y1 - 2008/1

N2 - In this paper, nicotinic acid, benzoic acid and p-nitrobenzoic applied in clinical were used as the model drugs. Small molecular drugs with carboxyl were PEGylated via degradable ester bonds by two-step process. The yield of products were 80%-85%. The small molecular drugs will be released by the degradation of ester bonds. The macromolecular prodrugs were characterized by IR, 1H-NMR and DSC. The results suggeste that small molecular drugs are conjugated to PEG. Products are dissolvable in most organic solvents such as CH2Cl2, THF, CH3CH2OH., CHCl3, CH3COCH3, DMF., DMSO. The solubility of the products has been improved in aqueous solutions. The example of PEG-(nicotinic acid)2 had been discussed detailedly.

AB - In this paper, nicotinic acid, benzoic acid and p-nitrobenzoic applied in clinical were used as the model drugs. Small molecular drugs with carboxyl were PEGylated via degradable ester bonds by two-step process. The yield of products were 80%-85%. The small molecular drugs will be released by the degradation of ester bonds. The macromolecular prodrugs were characterized by IR, 1H-NMR and DSC. The results suggeste that small molecular drugs are conjugated to PEG. Products are dissolvable in most organic solvents such as CH2Cl2, THF, CH3CH2OH., CHCl3, CH3COCH3, DMF., DMSO. The solubility of the products has been improved in aqueous solutions. The example of PEG-(nicotinic acid)2 had been discussed detailedly.

KW - Modification

KW - Nicotinic acid

KW - Polyethylene glycol

KW - Small molecule drugs

KW - Two-step process

UR - https://www.scopus.com/pages/publications/40449137144

M3 - 文章

AN - SCOPUS:40449137144

SN - 1000-7555

VL - 24

SP - 143

EP - 146

JO - Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering

JF - Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering

IS - 1

ER -

New method of PE gylated chemical medicine

Abstract

Keywords

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