New method for the synthesis of 5-hydroxycamptothecin derivatives

Xungui He; Heyong Gao; Wei Lu; Junchao Cai

doi:10.1081/SCC-200039356

New method for the synthesis of 5-hydroxycamptothecin derivatives

Xungui He
, Heyong Gao
, Wei Lu^*
, Junchao Cai

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

An efficient hydroxylation at the 5-position of the C ring of camptothecins was accomplished with the complex of CuI and organic amines as catalyst in the presence of oxygen at room temperature in dimethyl formate (DMF). To be successfully hydroxylated, the insoluble camptothecin analogue was transformed to the corresponding 20 carbonates.

Original language	English
Pages (from-to)	4285-4291
Number of pages	7
Journal	Synthetic Communications
Volume	34
Issue number	23
DOIs	https://doi.org/10.1081/SCC-200039356
State	Published - 2004
Externally published	Yes

Keywords

Antitumor
C ring
Camptothecin
Hydroxylation

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10.1081/SCC-200039356

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@article{358c6abddb2547d28e7d8b5d969aa1f8,

title = "New method for the synthesis of 5-hydroxycamptothecin derivatives",

abstract = "An efficient hydroxylation at the 5-position of the C ring of camptothecins was accomplished with the complex of CuI and organic amines as catalyst in the presence of oxygen at room temperature in dimethyl formate (DMF). To be successfully hydroxylated, the insoluble camptothecin analogue was transformed to the corresponding 20 carbonates.",

keywords = "Antitumor, C ring, Camptothecin, Hydroxylation",

author = "Xungui He and Heyong Gao and Wei Lu and Junchao Cai",

year = "2004",

doi = "10.1081/SCC-200039356",

language = "英语",

volume = "34",

pages = "4285--4291",

journal = "Synthetic Communications",

issn = "0039-7911",

publisher = "Taylor and Francis Ltd.",

number = "23",

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TY - JOUR

T1 - New method for the synthesis of 5-hydroxycamptothecin derivatives

AU - He, Xungui

AU - Gao, Heyong

AU - Lu, Wei

AU - Cai, Junchao

PY - 2004

Y1 - 2004

N2 - An efficient hydroxylation at the 5-position of the C ring of camptothecins was accomplished with the complex of CuI and organic amines as catalyst in the presence of oxygen at room temperature in dimethyl formate (DMF). To be successfully hydroxylated, the insoluble camptothecin analogue was transformed to the corresponding 20 carbonates.

AB - An efficient hydroxylation at the 5-position of the C ring of camptothecins was accomplished with the complex of CuI and organic amines as catalyst in the presence of oxygen at room temperature in dimethyl formate (DMF). To be successfully hydroxylated, the insoluble camptothecin analogue was transformed to the corresponding 20 carbonates.

KW - Antitumor

KW - C ring

KW - Camptothecin

KW - Hydroxylation

UR - https://www.scopus.com/pages/publications/10644282957

U2 - 10.1081/SCC-200039356

DO - 10.1081/SCC-200039356

M3 - 文章

AN - SCOPUS:10644282957

SN - 0039-7911

VL - 34

SP - 4285

EP - 4291

JO - Synthetic Communications

JF - Synthetic Communications

IS - 23

ER -

New method for the synthesis of 5-hydroxycamptothecin derivatives

Abstract

Keywords

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