New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases

Jian Lu; Xuyang Shang; Weiguo Zhong; Yuan Xu; Rong Shi; Xin Wang

doi:10.1016/j.apsb.2019.11.016

New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases

Jian Lu
, Xuyang Shang
, Weiguo Zhong
, Yuan Xu
, Rong Shi
, Xin Wang^*

^*Corresponding author for this work

School of Life Sciences

East China Normal University
Shanghai University of Traditional Chinese Medicine

Research output: Contribution to journal › Review article › peer-review

86 Scopus citations

Abstract

Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) for CYP1A genes may affect the metabolic ability of endogenous substances, leading to some physiological or pathological changes in humans. This review first summarizes the metabolism of endogenous substances by CYP1A, and then introduces the research progress of CYP1A SNPs, especially the research related to human diseases. Finally, the relationship between SNPs and diseases is discussed. In addition, potential animal models for CYP1A gene editing are summarized. In conclusion, CYP1A plays an important role in maintaining the health in the body.

Original language	English
Pages (from-to)	91-104
Number of pages	14
Journal	Acta Pharmaceutica Sinica B
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/j.apsb.2019.11.016
State	Published - Jan 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CYP1A
Endogenous substances
Metabolism and disease
SNPs
Xenobiotics

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10.1016/j.apsb.2019.11.016

Cite this

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title = "New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases",

abstract = "Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) for CYP1A genes may affect the metabolic ability of endogenous substances, leading to some physiological or pathological changes in humans. This review first summarizes the metabolism of endogenous substances by CYP1A, and then introduces the research progress of CYP1A SNPs, especially the research related to human diseases. Finally, the relationship between SNPs and diseases is discussed. In addition, potential animal models for CYP1A gene editing are summarized. In conclusion, CYP1A plays an important role in maintaining the health in the body.",

keywords = "CYP1A, Endogenous substances, Metabolism and disease, SNPs, Xenobiotics",

author = "Jian Lu and Xuyang Shang and Weiguo Zhong and Yuan Xu and Rong Shi and Xin Wang",

note = "Publisher Copyright: {\textcopyright} 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences",

year = "2020",

month = jan,

doi = "10.1016/j.apsb.2019.11.016",

language = "英语",

volume = "10",

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journal = "Acta Pharmaceutica Sinica B",

issn = "2211-3835",

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TY - JOUR

T1 - New insights of CYP1A in endogenous metabolism

T2 - a focus on single nucleotide polymorphisms and diseases

AU - Lu, Jian

AU - Shang, Xuyang

AU - Zhong, Weiguo

AU - Xu, Yuan

AU - Shi, Rong

AU - Wang, Xin

PY - 2020/1

Y1 - 2020/1

N2 - Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) for CYP1A genes may affect the metabolic ability of endogenous substances, leading to some physiological or pathological changes in humans. This review first summarizes the metabolism of endogenous substances by CYP1A, and then introduces the research progress of CYP1A SNPs, especially the research related to human diseases. Finally, the relationship between SNPs and diseases is discussed. In addition, potential animal models for CYP1A gene editing are summarized. In conclusion, CYP1A plays an important role in maintaining the health in the body.

AB - Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) for CYP1A genes may affect the metabolic ability of endogenous substances, leading to some physiological or pathological changes in humans. This review first summarizes the metabolism of endogenous substances by CYP1A, and then introduces the research progress of CYP1A SNPs, especially the research related to human diseases. Finally, the relationship between SNPs and diseases is discussed. In addition, potential animal models for CYP1A gene editing are summarized. In conclusion, CYP1A plays an important role in maintaining the health in the body.

KW - CYP1A

KW - Endogenous substances

KW - Metabolism and disease

KW - SNPs

KW - Xenobiotics

UR - https://www.scopus.com/pages/publications/85076825394

U2 - 10.1016/j.apsb.2019.11.016

DO - 10.1016/j.apsb.2019.11.016

M3 - 文献综述

AN - SCOPUS:85076825394

SN - 2211-3835

VL - 10

SP - 91

EP - 104

JO - Acta Pharmaceutica Sinica B

JF - Acta Pharmaceutica Sinica B

IS - 1

ER -

New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases

Abstract

UN SDGs

Keywords

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