TY - JOUR
T1 - New insights of CYP1A in endogenous metabolism
T2 - a focus on single nucleotide polymorphisms and diseases
AU - Lu, Jian
AU - Shang, Xuyang
AU - Zhong, Weiguo
AU - Xu, Yuan
AU - Shi, Rong
AU - Wang, Xin
N1 - Publisher Copyright:
© 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences
PY - 2020/1
Y1 - 2020/1
N2 - Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) for CYP1A genes may affect the metabolic ability of endogenous substances, leading to some physiological or pathological changes in humans. This review first summarizes the metabolism of endogenous substances by CYP1A, and then introduces the research progress of CYP1A SNPs, especially the research related to human diseases. Finally, the relationship between SNPs and diseases is discussed. In addition, potential animal models for CYP1A gene editing are summarized. In conclusion, CYP1A plays an important role in maintaining the health in the body.
AB - Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) for CYP1A genes may affect the metabolic ability of endogenous substances, leading to some physiological or pathological changes in humans. This review first summarizes the metabolism of endogenous substances by CYP1A, and then introduces the research progress of CYP1A SNPs, especially the research related to human diseases. Finally, the relationship between SNPs and diseases is discussed. In addition, potential animal models for CYP1A gene editing are summarized. In conclusion, CYP1A plays an important role in maintaining the health in the body.
KW - CYP1A
KW - Endogenous substances
KW - Metabolism and disease
KW - SNPs
KW - Xenobiotics
UR - https://www.scopus.com/pages/publications/85076825394
U2 - 10.1016/j.apsb.2019.11.016
DO - 10.1016/j.apsb.2019.11.016
M3 - 文献综述
AN - SCOPUS:85076825394
SN - 2211-3835
VL - 10
SP - 91
EP - 104
JO - Acta Pharmaceutica Sinica B
JF - Acta Pharmaceutica Sinica B
IS - 1
ER -
