TY - JOUR
T1 - Neohesperidin Dihydrochalcone Improves Hyperglycemia and Insulin Resistance in Diabetic Zebrafish
AU - Tao, Fuying
AU - Wang, Pei
AU - Dai, Ziru
AU - Zhang, Chenxiao
AU - Li, Dongliang
AU - Fan, Heliang
AU - Qin, Mei
AU - Qi, Cen
AU - Hao, Junguang
N1 - Publisher Copyright:
© 2023 The Authors. Published by American Chemical Society.
PY - 2023/9/15
Y1 - 2023/9/15
N2 - Neohesperidin dihydrochalcone (NHDC), a bicyclic flavonoid compound, has many important physiological functions. However, the underlying hypoglycemic mechanism of NHDC is not clear. We investigated the mechanism underlying the antihyperglycemic effects of NHDC by cloning diabetic zebrafish. NHDC (0.5 mg/mL) substantially alleviated hyperglycemia and hyperinsulinemia in diabetic zebrafish, reduced fasting blood glucose, glycated serum protein, serum glucose, triacylglycerol, cholesterol, and insulin levels and HOMA-IR, TNF-α, IL-6, G6P, and PEPCK activities, and increased GCK activity. Histological examination of hepatic tissues showed that NHDC substantially reduced diabetes-exacerbated lipid accumulation in liver tissues. Transcriptomic and polymerase chain reaction analyses indicated that NHDC improves insulin resistance possibly by activating the insulin pathway (PI3K/AKT) and regulating glucolipid metabolism and inflammatory responses. This study demonstrated the anti-insulin resistance properties of NHDC and its effect on hyperglycemia and hypolipidemia, providing new insights into the antidiabetic effects of NHDC and its use as a dietary supplement for diabetic therapy.
AB - Neohesperidin dihydrochalcone (NHDC), a bicyclic flavonoid compound, has many important physiological functions. However, the underlying hypoglycemic mechanism of NHDC is not clear. We investigated the mechanism underlying the antihyperglycemic effects of NHDC by cloning diabetic zebrafish. NHDC (0.5 mg/mL) substantially alleviated hyperglycemia and hyperinsulinemia in diabetic zebrafish, reduced fasting blood glucose, glycated serum protein, serum glucose, triacylglycerol, cholesterol, and insulin levels and HOMA-IR, TNF-α, IL-6, G6P, and PEPCK activities, and increased GCK activity. Histological examination of hepatic tissues showed that NHDC substantially reduced diabetes-exacerbated lipid accumulation in liver tissues. Transcriptomic and polymerase chain reaction analyses indicated that NHDC improves insulin resistance possibly by activating the insulin pathway (PI3K/AKT) and regulating glucolipid metabolism and inflammatory responses. This study demonstrated the anti-insulin resistance properties of NHDC and its effect on hyperglycemia and hypolipidemia, providing new insights into the antidiabetic effects of NHDC and its use as a dietary supplement for diabetic therapy.
KW - diabetic zebrafish
KW - dietary supplement
KW - hyperglycemia
KW - improve
KW - insulin resistance
KW - neohesperidin dihydrochalcone
UR - https://www.scopus.com/pages/publications/85168992956
U2 - 10.1021/acsfoodscitech.3c00200
DO - 10.1021/acsfoodscitech.3c00200
M3 - 文章
AN - SCOPUS:85168992956
SN - 2692-1944
VL - 3
SP - 1548
EP - 1558
JO - ACS Food Science and Technology
JF - ACS Food Science and Technology
IS - 9
ER -
