Near-infrared laser/H2O2 dual-responsive multifunctional mesoporous polydopamine nanoparticles for tumor photothermal/chemodynamic/CO combination therapy

Lan Yang; Yanpeng Zhu; Aijing Ma; Wei Gao; Zhaoyang Guo; Yujia Xin; Ruixue Ran; Xiaoying Yang

doi:10.1016/j.jphotochem.2022.114341

Near-infrared laser/H₂O₂ dual-responsive multifunctional mesoporous polydopamine nanoparticles for tumor photothermal/chemodynamic/CO combination therapy

Lan Yang
, Yanpeng Zhu
, Aijing Ma
, Wei Gao
, Zhaoyang Guo
, Yujia Xin
, Ruixue Ran^*
, Xiaoying Yang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The multifunctional MPDA/ReCO/CS/PEG nanoparticles were constructed by loading Re₂(CO)₁₀ and ultra-small Cu_2-xSe into mesoporous polydopamine (MPDA) nanoparticles through the chelating effect of the catechol groups in MPDA nanoparticles and metal ions with subsequent surface modification with polyethylene glycol (PEG). The multifunctional MPDA/ReCO/CS/PEG nanoparticles enable a controlled release of CO and simultaneously generate ROS triggered by near-infrared (NIR) laser and H₂O₂ enriched in the tumor microenvironment. They exhibited highly desirable combined anticancer effect and superior therapeutic safety both in vitro and in vivo. The multifunctional nanoparticles mediated photothermal/chemodynamic/CO combination therapy, which can be activated at tumor sites, providing a promising strategy for cancer treatment.

Original language	English
Article number	114341
Journal	Journal of Photochemistry and Photobiology A: Chemistry
Volume	435
DOIs	https://doi.org/10.1016/j.jphotochem.2022.114341
State	Published - 1 Feb 2023
Externally published	Yes

Keywords

Chemodynamic therapy
CO therapy
Mesoporous polydopamine nanoparticles
Photothermal therapy
Tumor combination therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jphotochem.2022.114341

Cite this

@article{0bab2dd9e88e432ebd82f6a7e792dd83,

title = "Near-infrared laser/H2O2 dual-responsive multifunctional mesoporous polydopamine nanoparticles for tumor photothermal/chemodynamic/CO combination therapy",

abstract = "The multifunctional MPDA/ReCO/CS/PEG nanoparticles were constructed by loading Re2(CO)10 and ultra-small Cu2-xSe into mesoporous polydopamine (MPDA) nanoparticles through the chelating effect of the catechol groups in MPDA nanoparticles and metal ions with subsequent surface modification with polyethylene glycol (PEG). The multifunctional MPDA/ReCO/CS/PEG nanoparticles enable a controlled release of CO and simultaneously generate ROS triggered by near-infrared (NIR) laser and H2O2 enriched in the tumor microenvironment. They exhibited highly desirable combined anticancer effect and superior therapeutic safety both in vitro and in vivo. The multifunctional nanoparticles mediated photothermal/chemodynamic/CO combination therapy, which can be activated at tumor sites, providing a promising strategy for cancer treatment.",

keywords = "Chemodynamic therapy, CO therapy, Mesoporous polydopamine nanoparticles, Photothermal therapy, Tumor combination therapy",

author = "Lan Yang and Yanpeng Zhu and Aijing Ma and Wei Gao and Zhaoyang Guo and Yujia Xin and Ruixue Ran and Xiaoying Yang",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2023",

month = feb,

day = "1",

doi = "10.1016/j.jphotochem.2022.114341",

language = "英语",

volume = "435",

journal = "Journal of Photochemistry and Photobiology A: Chemistry",

issn = "1010-6030",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Near-infrared laser/H2O2 dual-responsive multifunctional mesoporous polydopamine nanoparticles for tumor photothermal/chemodynamic/CO combination therapy

AU - Yang, Lan

AU - Zhu, Yanpeng

AU - Ma, Aijing

AU - Gao, Wei

AU - Guo, Zhaoyang

AU - Xin, Yujia

AU - Ran, Ruixue

AU - Yang, Xiaoying

PY - 2023/2/1

Y1 - 2023/2/1

N2 - The multifunctional MPDA/ReCO/CS/PEG nanoparticles were constructed by loading Re2(CO)10 and ultra-small Cu2-xSe into mesoporous polydopamine (MPDA) nanoparticles through the chelating effect of the catechol groups in MPDA nanoparticles and metal ions with subsequent surface modification with polyethylene glycol (PEG). The multifunctional MPDA/ReCO/CS/PEG nanoparticles enable a controlled release of CO and simultaneously generate ROS triggered by near-infrared (NIR) laser and H2O2 enriched in the tumor microenvironment. They exhibited highly desirable combined anticancer effect and superior therapeutic safety both in vitro and in vivo. The multifunctional nanoparticles mediated photothermal/chemodynamic/CO combination therapy, which can be activated at tumor sites, providing a promising strategy for cancer treatment.

AB - The multifunctional MPDA/ReCO/CS/PEG nanoparticles were constructed by loading Re2(CO)10 and ultra-small Cu2-xSe into mesoporous polydopamine (MPDA) nanoparticles through the chelating effect of the catechol groups in MPDA nanoparticles and metal ions with subsequent surface modification with polyethylene glycol (PEG). The multifunctional MPDA/ReCO/CS/PEG nanoparticles enable a controlled release of CO and simultaneously generate ROS triggered by near-infrared (NIR) laser and H2O2 enriched in the tumor microenvironment. They exhibited highly desirable combined anticancer effect and superior therapeutic safety both in vitro and in vivo. The multifunctional nanoparticles mediated photothermal/chemodynamic/CO combination therapy, which can be activated at tumor sites, providing a promising strategy for cancer treatment.

KW - Chemodynamic therapy

KW - CO therapy

KW - Mesoporous polydopamine nanoparticles

KW - Photothermal therapy

KW - Tumor combination therapy

UR - https://www.scopus.com/pages/publications/85139841945

U2 - 10.1016/j.jphotochem.2022.114341

DO - 10.1016/j.jphotochem.2022.114341

M3 - 文章

AN - SCOPUS:85139841945

SN - 1010-6030

VL - 435

JO - Journal of Photochemistry and Photobiology A: Chemistry

JF - Journal of Photochemistry and Photobiology A: Chemistry

M1 - 114341

ER -