Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2

Huimin Li; Huilin Guo; Chang Lei; Li Liu; Liqin Xu; Yaping Feng; Jin Ke; Wei Fang; Hao Song; Chun Xu; Chengzhong Yu; Xing Long

doi:10.1002/adma.201904535

Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2

Huimin Li, Huilin Guo, Chang Lei, Li Liu, Liqin Xu, Yaping Feng, Jin Ke, Wei Fang, Hao Song, Chun Xu^*, Chengzhong Yu, Xing Long

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Osteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi-injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme, hyaluronan synthase type 2 (HAS2), into synoviocytes from the temporomandibular joint (TMJ) and generate endogenous HA with high molecular weights. In a rat TMJ osteoarthritis inflammation model, this strategy promotes endogenous HA production and inhibits the synovial inflammation of OA for more than 3 weeks with one-shot administration. Such nanotherapy also helps repairing the bone defects in a rat OA bone defect model.

Original language	English
Article number	1904535
Journal	Advanced Materials
Volume	31
Issue number	46
DOIs	https://doi.org/10.1002/adma.201904535
State	Published - 1 Nov 2019
Externally published	Yes

Keywords

drug carriers
hyaluronic acid
nanoparticles
osteoarthritis
protein delivery

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10.1002/adma.201904535

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title = "Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2",

abstract = "Osteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi-injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme, hyaluronan synthase type 2 (HAS2), into synoviocytes from the temporomandibular joint (TMJ) and generate endogenous HA with high molecular weights. In a rat TMJ osteoarthritis inflammation model, this strategy promotes endogenous HA production and inhibits the synovial inflammation of OA for more than 3 weeks with one-shot administration. Such nanotherapy also helps repairing the bone defects in a rat OA bone defect model.",

keywords = "drug carriers, hyaluronic acid, nanoparticles, osteoarthritis, protein delivery",

author = "Huimin Li and Huilin Guo and Chang Lei and Li Liu and Liqin Xu and Yaping Feng and Jin Ke and Wei Fang and Hao Song and Chun Xu and Chengzhong Yu and Xing Long",

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year = "2019",

month = nov,

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doi = "10.1002/adma.201904535",

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T2 - Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2

AU - Li, Huimin

AU - Guo, Huilin

AU - Lei, Chang

AU - Liu, Li

AU - Xu, Liqin

AU - Feng, Yaping

AU - Ke, Jin

AU - Fang, Wei

AU - Song, Hao

AU - Xu, Chun

AU - Yu, Chengzhong

AU - Long, Xing

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Osteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi-injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme, hyaluronan synthase type 2 (HAS2), into synoviocytes from the temporomandibular joint (TMJ) and generate endogenous HA with high molecular weights. In a rat TMJ osteoarthritis inflammation model, this strategy promotes endogenous HA production and inhibits the synovial inflammation of OA for more than 3 weeks with one-shot administration. Such nanotherapy also helps repairing the bone defects in a rat OA bone defect model.

AB - Osteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi-injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme, hyaluronan synthase type 2 (HAS2), into synoviocytes from the temporomandibular joint (TMJ) and generate endogenous HA with high molecular weights. In a rat TMJ osteoarthritis inflammation model, this strategy promotes endogenous HA production and inhibits the synovial inflammation of OA for more than 3 weeks with one-shot administration. Such nanotherapy also helps repairing the bone defects in a rat OA bone defect model.

KW - drug carriers

KW - hyaluronic acid

KW - nanoparticles

KW - osteoarthritis

KW - protein delivery

UR - https://www.scopus.com/pages/publications/85074033635

U2 - 10.1002/adma.201904535

DO - 10.1002/adma.201904535

M3 - 文章

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AN - SCOPUS:85074033635

SN - 0935-9648

VL - 31

JO - Advanced Materials

JF - Advanced Materials

IS - 46

M1 - 1904535

ER -

Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2

Abstract

Keywords

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