Nanochemistry Modulates Intracellular Decomposition Routes of S-Nitrosothiol Modified Silica-Based Nanoparticles

Shevanuja Theivendran; Chengzhong Yu

doi:10.1002/smll.202007671

Nanochemistry Modulates Intracellular Decomposition Routes of S-Nitrosothiol Modified Silica-Based Nanoparticles

Shevanuja Theivendran
, Chengzhong Yu^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

University of Queensland

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Cellular delivery of nitric oxide (NO) using NO donor moieties such as S-nitrosothiol (SNO) is of great interest for various applications. However, understandings of the intracellular decomposition routes of SNO toward either NO or ammonia (NH₃) production are surprisingly scarce. Herein, the first report of SNO modified mesoporous organosilica nanoparticles with tetrasulfide bonds for enhanced intracellular NO delivery, ≈10 times higher than a commercial NO donor, is presented. The tetrasulfide chemistry modulates the SNO decomposition by shifting from NH₃ to NO production in glutathione rich cancer cells. This study provides a new strategy to control the NO level in biological systems.

Original language	English
Article number	2007671
Journal	Small
Volume	17
Issue number	21
DOIs	https://doi.org/10.1002/smll.202007671
State	Published - 27 May 2021

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

NO donor
cancer therapy
organosilica
s-nitrosothiol

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10.1002/smll.202007671

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abstract = "Cellular delivery of nitric oxide (NO) using NO donor moieties such as S-nitrosothiol (SNO) is of great interest for various applications. However, understandings of the intracellular decomposition routes of SNO toward either NO or ammonia (NH3) production are surprisingly scarce. Herein, the first report of SNO modified mesoporous organosilica nanoparticles with tetrasulfide bonds for enhanced intracellular NO delivery, ≈10 times higher than a commercial NO donor, is presented. The tetrasulfide chemistry modulates the SNO decomposition by shifting from NH3 to NO production in glutathione rich cancer cells. This study provides a new strategy to control the NO level in biological systems.",

keywords = "NO donor, cancer therapy, organosilica, s-nitrosothiol",

author = "Shevanuja Theivendran and Chengzhong Yu",

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doi = "10.1002/smll.202007671",

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AU - Theivendran, Shevanuja

AU - Yu, Chengzhong

PY - 2021/5/27

Y1 - 2021/5/27

N2 - Cellular delivery of nitric oxide (NO) using NO donor moieties such as S-nitrosothiol (SNO) is of great interest for various applications. However, understandings of the intracellular decomposition routes of SNO toward either NO or ammonia (NH3) production are surprisingly scarce. Herein, the first report of SNO modified mesoporous organosilica nanoparticles with tetrasulfide bonds for enhanced intracellular NO delivery, ≈10 times higher than a commercial NO donor, is presented. The tetrasulfide chemistry modulates the SNO decomposition by shifting from NH3 to NO production in glutathione rich cancer cells. This study provides a new strategy to control the NO level in biological systems.

AB - Cellular delivery of nitric oxide (NO) using NO donor moieties such as S-nitrosothiol (SNO) is of great interest for various applications. However, understandings of the intracellular decomposition routes of SNO toward either NO or ammonia (NH3) production are surprisingly scarce. Herein, the first report of SNO modified mesoporous organosilica nanoparticles with tetrasulfide bonds for enhanced intracellular NO delivery, ≈10 times higher than a commercial NO donor, is presented. The tetrasulfide chemistry modulates the SNO decomposition by shifting from NH3 to NO production in glutathione rich cancer cells. This study provides a new strategy to control the NO level in biological systems.

KW - NO donor

KW - cancer therapy

KW - organosilica

KW - s-nitrosothiol

UR - https://www.scopus.com/pages/publications/85104301783

U2 - 10.1002/smll.202007671

DO - 10.1002/smll.202007671

M3 - 文章

C2 - 33860647

AN - SCOPUS:85104301783

SN - 1613-6810

VL - 17

JO - Small

JF - Small

IS - 21

M1 - 2007671

ER -

Nanochemistry Modulates Intracellular Decomposition Routes of S-Nitrosothiol Modified Silica-Based Nanoparticles

Abstract

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Keywords

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