Nanocapsules based on mPEGylated artesunate prodrug and its cytotoxicity

Haijing Meng; Ke Xu; Yanyun Xu; Ping Luo; Fang Du; Jin Huang; Wei Lu; Jiahui Yu; Shiyuan Liu; Ben Muir

doi:10.1016/j.colsurfb.2013.11.039

Nanocapsules based on mPEGylated artesunate prodrug and its cytotoxicity

Haijing Meng, Ke Xu, Yanyun Xu, Ping Luo, Fang Du, Jin Huang, Wei Lu, Jiahui Yu, Shiyuan Liu, Ben Muir

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

mPEGylated artesunate prodrug was synthesized via esterification between poly(ethylene glycol) monomethyl ether (mPEG) and artesunate (ART). The product was inclined to form nanocapsules in aqueous media due to its amphiphilic nature. These nanocapsules showed narrow size distribution, with an average particle size of 88.7. nm measured by dynamic laser scattering (DLS). Their vesical morphology was further confirmed by transmission electron microscopy (TEM). We found that the release of ART from the nanocapsules was controllable, which was contributed to the easily hydrolyzed property of the ester bond. In addition, the cytotoxicity of the prodrug against L1210 and MCF7 cell lines showed an essential decrease compared with the free ART. These results present a new strategy in designing anti-tumor ART nanocapsules for targeting tumor cells.

Original language	English
Pages (from-to)	164-169
Number of pages	6
Journal	Colloids and Surfaces B: Biointerfaces
Volume	115
DOIs	https://doi.org/10.1016/j.colsurfb.2013.11.039
State	Published - 1 Mar 2014

Keywords

Artesunate
Controllable release
MPEGylation
Nanocapsules
Passive targeting

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10.1016/j.colsurfb.2013.11.039

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title = "Nanocapsules based on mPEGylated artesunate prodrug and its cytotoxicity",

abstract = "mPEGylated artesunate prodrug was synthesized via esterification between poly(ethylene glycol) monomethyl ether (mPEG) and artesunate (ART). The product was inclined to form nanocapsules in aqueous media due to its amphiphilic nature. These nanocapsules showed narrow size distribution, with an average particle size of 88.7. nm measured by dynamic laser scattering (DLS). Their vesical morphology was further confirmed by transmission electron microscopy (TEM). We found that the release of ART from the nanocapsules was controllable, which was contributed to the easily hydrolyzed property of the ester bond. In addition, the cytotoxicity of the prodrug against L1210 and MCF7 cell lines showed an essential decrease compared with the free ART. These results present a new strategy in designing anti-tumor ART nanocapsules for targeting tumor cells.",

keywords = "Artesunate, Controllable release, MPEGylation, Nanocapsules, Passive targeting",

author = "Haijing Meng and Ke Xu and Yanyun Xu and Ping Luo and Fang Du and Jin Huang and Wei Lu and Jiahui Yu and Shiyuan Liu and Ben Muir",

year = "2014",

month = mar,

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doi = "10.1016/j.colsurfb.2013.11.039",

language = "英语",

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TY - JOUR

T1 - Nanocapsules based on mPEGylated artesunate prodrug and its cytotoxicity

AU - Meng, Haijing

AU - Xu, Ke

AU - Xu, Yanyun

AU - Luo, Ping

AU - Du, Fang

AU - Huang, Jin

AU - Lu, Wei

AU - Yu, Jiahui

AU - Liu, Shiyuan

AU - Muir, Ben

PY - 2014/3/1

Y1 - 2014/3/1

N2 - mPEGylated artesunate prodrug was synthesized via esterification between poly(ethylene glycol) monomethyl ether (mPEG) and artesunate (ART). The product was inclined to form nanocapsules in aqueous media due to its amphiphilic nature. These nanocapsules showed narrow size distribution, with an average particle size of 88.7. nm measured by dynamic laser scattering (DLS). Their vesical morphology was further confirmed by transmission electron microscopy (TEM). We found that the release of ART from the nanocapsules was controllable, which was contributed to the easily hydrolyzed property of the ester bond. In addition, the cytotoxicity of the prodrug against L1210 and MCF7 cell lines showed an essential decrease compared with the free ART. These results present a new strategy in designing anti-tumor ART nanocapsules for targeting tumor cells.

AB - mPEGylated artesunate prodrug was synthesized via esterification between poly(ethylene glycol) monomethyl ether (mPEG) and artesunate (ART). The product was inclined to form nanocapsules in aqueous media due to its amphiphilic nature. These nanocapsules showed narrow size distribution, with an average particle size of 88.7. nm measured by dynamic laser scattering (DLS). Their vesical morphology was further confirmed by transmission electron microscopy (TEM). We found that the release of ART from the nanocapsules was controllable, which was contributed to the easily hydrolyzed property of the ester bond. In addition, the cytotoxicity of the prodrug against L1210 and MCF7 cell lines showed an essential decrease compared with the free ART. These results present a new strategy in designing anti-tumor ART nanocapsules for targeting tumor cells.

KW - Artesunate

KW - Controllable release

KW - MPEGylation

KW - Nanocapsules

KW - Passive targeting

UR - https://www.scopus.com/pages/publications/84890262109

U2 - 10.1016/j.colsurfb.2013.11.039

DO - 10.1016/j.colsurfb.2013.11.039

M3 - 文章

C2 - 24334269

AN - SCOPUS:84890262109

SN - 0927-7765

VL - 115

SP - 164

EP - 169

JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

ER -

Nanocapsules based on mPEGylated artesunate prodrug and its cytotoxicity

Abstract

Keywords

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