N-Aroyloxynaphthalimides as novel highly efficient DNA photocleavers: Substituent effects

Xuhong Qian; Wei Yao; Gang Chen; Xiayu Huang; Ping Mao

doi:10.1016/S0040-4039(01)01214-X

N-Aroyloxynaphthalimides as novel highly efficient DNA photocleavers: Substituent effects

Xuhong Qian, Wei Yao, Gang Chen, Xiayu Huang, Ping Mao

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A novel DNA photocleaver family of N-benzoyloxythioxonaphthalimides, which show improved DNA intercalation and photocleaving activity compared with their oxo- counterparts, were synthesized and evaluated. The substituents on the benzene ring of the benzoyloxy moiety have an important and unusual influence on the DNA photocleaving activity. N-(p-Methoxylbenzoyloxy)thioxonaphthalimide is able to photocleave DNA at low concentration (5 μM) with 'time-resolved' and pH independent properties.

Original language	English
Pages (from-to)	6175-6178
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	35
DOIs	https://doi.org/10.1016/S0040-4039(01)01214-X
State	Published - 27 Aug 2001
Externally published	Yes

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title = "N-Aroyloxynaphthalimides as novel highly efficient DNA photocleavers: Substituent effects",

abstract = "A novel DNA photocleaver family of N-benzoyloxythioxonaphthalimides, which show improved DNA intercalation and photocleaving activity compared with their oxo- counterparts, were synthesized and evaluated. The substituents on the benzene ring of the benzoyloxy moiety have an important and unusual influence on the DNA photocleaving activity. N-(p-Methoxylbenzoyloxy)thioxonaphthalimide is able to photocleave DNA at low concentration (5 μM) with 'time-resolved' and pH independent properties.",

author = "Xuhong Qian and Wei Yao and Gang Chen and Xiayu Huang and Ping Mao",

year = "2001",

month = aug,

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doi = "10.1016/S0040-4039(01)01214-X",

language = "英语",

volume = "42",

pages = "6175--6178",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "35",

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TY - JOUR

T1 - N-Aroyloxynaphthalimides as novel highly efficient DNA photocleavers

T2 - Substituent effects

AU - Qian, Xuhong

AU - Yao, Wei

AU - Chen, Gang

AU - Huang, Xiayu

AU - Mao, Ping

PY - 2001/8/27

Y1 - 2001/8/27

N2 - A novel DNA photocleaver family of N-benzoyloxythioxonaphthalimides, which show improved DNA intercalation and photocleaving activity compared with their oxo- counterparts, were synthesized and evaluated. The substituents on the benzene ring of the benzoyloxy moiety have an important and unusual influence on the DNA photocleaving activity. N-(p-Methoxylbenzoyloxy)thioxonaphthalimide is able to photocleave DNA at low concentration (5 μM) with 'time-resolved' and pH independent properties.

AB - A novel DNA photocleaver family of N-benzoyloxythioxonaphthalimides, which show improved DNA intercalation and photocleaving activity compared with their oxo- counterparts, were synthesized and evaluated. The substituents on the benzene ring of the benzoyloxy moiety have an important and unusual influence on the DNA photocleaving activity. N-(p-Methoxylbenzoyloxy)thioxonaphthalimide is able to photocleave DNA at low concentration (5 μM) with 'time-resolved' and pH independent properties.

UR - https://www.scopus.com/pages/publications/0035959471

U2 - 10.1016/S0040-4039(01)01214-X

DO - 10.1016/S0040-4039(01)01214-X

M3 - 文章

AN - SCOPUS:0035959471

SN - 0040-4039

VL - 42

SP - 6175

EP - 6178

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 35

ER -

N-Aroyloxynaphthalimides as novel highly efficient DNA photocleavers: Substituent effects

Abstract

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