Multivalent Aptamer-modified DNA Origami as Drug Delivery System for Targeted Cancer Therapy

Mengyao Cao; Yueyang Sun; Mingshu Xiao; Li Li; Xiaohui Liu; Hong Jin; Hao Pei

doi:10.1007/s40242-019-9273-4

Multivalent Aptamer-modified DNA Origami as Drug Delivery System for Targeted Cancer Therapy

Mengyao Cao, Yueyang Sun, Mingshu Xiao, Li Li, Xiaohui Liu, Hong Jin, Hao Pei^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

In spite of great development in nanoparticle-based drug delivery systems(DDSs) for improved therapeutic efficacy, it remains challenging for effective delivery of chemotherapeutic drugs to targeted tumor cells. In this work, we report a triangle DNA origami as targeted DDS for cancer therapy. DNA origami shows excellent biocompatibility and stability in cell culture medium for 24 h. In addition, the DNA origami structures conjugated with multivalent aptamers enable for efficient delivery of anticancer drug doxorubicin(Dox) into targeted cancer cell due to their targeting function, reducing side effects associated with nonspecific distribution. Moreover, we also demonstrated that the multivalent aptamer-modified DNA origami loading Dox exhibits prominent therapeutic efficacy in vitro. Accordingly, this work provides a good paradigm for the development of DNA origami nanostructure-based targeted DDS for cancer therapy.

Original language	English
Pages (from-to)	254-260
Number of pages	7
Journal	Chemical Research in Chinese Universities
Volume	36
Issue number	2
DOIs	https://doi.org/10.1007/s40242-019-9273-4
State	Published - 1 Apr 2020

Keywords

Aptamer
DNA origami
Targeted drug delivery system

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s40242-019-9273-4

Cite this

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title = "Multivalent Aptamer-modified DNA Origami as Drug Delivery System for Targeted Cancer Therapy",

abstract = "In spite of great development in nanoparticle-based drug delivery systems(DDSs) for improved therapeutic efficacy, it remains challenging for effective delivery of chemotherapeutic drugs to targeted tumor cells. In this work, we report a triangle DNA origami as targeted DDS for cancer therapy. DNA origami shows excellent biocompatibility and stability in cell culture medium for 24 h. In addition, the DNA origami structures conjugated with multivalent aptamers enable for efficient delivery of anticancer drug doxorubicin(Dox) into targeted cancer cell due to their targeting function, reducing side effects associated with nonspecific distribution. Moreover, we also demonstrated that the multivalent aptamer-modified DNA origami loading Dox exhibits prominent therapeutic efficacy in vitro. Accordingly, this work provides a good paradigm for the development of DNA origami nanostructure-based targeted DDS for cancer therapy.",

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doi = "10.1007/s40242-019-9273-4",

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T1 - Multivalent Aptamer-modified DNA Origami as Drug Delivery System for Targeted Cancer Therapy

AU - Cao, Mengyao

AU - Sun, Yueyang

AU - Xiao, Mingshu

AU - Li, Li

AU - Liu, Xiaohui

AU - Jin, Hong

AU - Pei, Hao

PY - 2020/4/1

Y1 - 2020/4/1

N2 - In spite of great development in nanoparticle-based drug delivery systems(DDSs) for improved therapeutic efficacy, it remains challenging for effective delivery of chemotherapeutic drugs to targeted tumor cells. In this work, we report a triangle DNA origami as targeted DDS for cancer therapy. DNA origami shows excellent biocompatibility and stability in cell culture medium for 24 h. In addition, the DNA origami structures conjugated with multivalent aptamers enable for efficient delivery of anticancer drug doxorubicin(Dox) into targeted cancer cell due to their targeting function, reducing side effects associated with nonspecific distribution. Moreover, we also demonstrated that the multivalent aptamer-modified DNA origami loading Dox exhibits prominent therapeutic efficacy in vitro. Accordingly, this work provides a good paradigm for the development of DNA origami nanostructure-based targeted DDS for cancer therapy.

AB - In spite of great development in nanoparticle-based drug delivery systems(DDSs) for improved therapeutic efficacy, it remains challenging for effective delivery of chemotherapeutic drugs to targeted tumor cells. In this work, we report a triangle DNA origami as targeted DDS for cancer therapy. DNA origami shows excellent biocompatibility and stability in cell culture medium for 24 h. In addition, the DNA origami structures conjugated with multivalent aptamers enable for efficient delivery of anticancer drug doxorubicin(Dox) into targeted cancer cell due to their targeting function, reducing side effects associated with nonspecific distribution. Moreover, we also demonstrated that the multivalent aptamer-modified DNA origami loading Dox exhibits prominent therapeutic efficacy in vitro. Accordingly, this work provides a good paradigm for the development of DNA origami nanostructure-based targeted DDS for cancer therapy.

KW - Aptamer

KW - DNA origami

KW - Targeted drug delivery system

UR - https://www.scopus.com/pages/publications/85075350941

U2 - 10.1007/s40242-019-9273-4

DO - 10.1007/s40242-019-9273-4

M3 - 文章

AN - SCOPUS:85075350941

SN - 1005-9040

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JO - Chemical Research in Chinese Universities

JF - Chemical Research in Chinese Universities

IS - 2

ER -

Multivalent Aptamer-modified DNA Origami as Drug Delivery System for Targeted Cancer Therapy

Abstract

Keywords

UN SDGs

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