Multifunctional graphene oxide-based triple stimuli-responsive nanotheranostics

Yu Chen; Pengfei Xu; Zhu Shu; Meiying Wu; Lianzhou Wang; Shengjian Zhang; Yuanyi Zheng; Hangrong Chen; Jin Wang; Yaping Li; Jianlin Shi

doi:10.1002/adfm.201400221

Multifunctional graphene oxide-based triple stimuli-responsive nanotheranostics

Yu Chen
, Pengfei Xu
, Zhu Shu
, Meiying Wu
, Lianzhou Wang
, Shengjian Zhang
, Yuanyi Zheng
, Hangrong Chen^*
, Jin Wang
, Yaping Li
, Jianlin Shi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

Construction of multifunctional stimuli-responsive nanosystems intelligently responsive to inner physiological and/or external irradiations based on nanobiotechnology can enable the on-demand drug release and improved diagnostic imaging to mitigate the side-effects of anticancer drugs and enhance the diagnostic/therapeutic outcome simultaneously. Here, a triple-functional stimuli-responsive nanosystem based on the co-integration of superparamagnetic Fe₃O₄ and paramagnetic MnO_x nanoparticles (NPs) onto exfoliated graphene oxide (GO) nanosheets by a novel and efficient double redox strategy (DRS) is reported. Aromatic anticancer drug molecules can interact with GO nanosheets through supramolecular π stacking to achieve high drug loading capacity and pH-responsive drug releasing performance. The integrated MnO_x NPs can disintegrate in mild acidic and reduction environment to realize the highly efficient pH-responsive and reduction-triggered T₁-weighted magnetic resonance imaging (MRI). Superparamagnetic Fe₃O₄ NPs can not only function as the T₂-weighted contrast agents for MRI, but also response to the external magnetic field for magnetic hyperthermia against cancer. Importantly, the constructed biocompatible GO-based nanoplatform can inhibit the metastasis of cancer cells by downregulating the expression of metastasis-related proteins, and anticancer drug-loaded carrier can significantly reverse the multidrug resistance (MDR) of cancer cells. A triple-functional biocompatible stimuli-responsive nanosystem based on the functionalized nanographene oxides is developed by a novel and efficient double redox strategy. This elaborately designed nanographene oxide-based nanoplatform exhibits the unique triple stimuli-responsivenesses for biomedical engineering, including pH-responsive drug release to inhibit the metastasis and reverse the multidrug resistance of cancer cells, pH-/redox-responsive magnetic resonance imaging and magnetic field-responsive hyperthermia of cancer.

Original language	English
Pages (from-to)	4386-4396
Number of pages	11
Journal	Advanced Functional Materials
Volume	24
Issue number	28
DOIs	https://doi.org/10.1002/adfm.201400221
State	Published - 23 Jul 2014
Externally published	Yes

Keywords

MRI
cancer therapy
graphene oxide
hyperthermia
stimuli-responsiveness

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adfm.201400221

Cite this

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title = "Multifunctional graphene oxide-based triple stimuli-responsive nanotheranostics",

abstract = "Construction of multifunctional stimuli-responsive nanosystems intelligently responsive to inner physiological and/or external irradiations based on nanobiotechnology can enable the on-demand drug release and improved diagnostic imaging to mitigate the side-effects of anticancer drugs and enhance the diagnostic/therapeutic outcome simultaneously. Here, a triple-functional stimuli-responsive nanosystem based on the co-integration of superparamagnetic Fe3O4 and paramagnetic MnOx nanoparticles (NPs) onto exfoliated graphene oxide (GO) nanosheets by a novel and efficient double redox strategy (DRS) is reported. Aromatic anticancer drug molecules can interact with GO nanosheets through supramolecular π stacking to achieve high drug loading capacity and pH-responsive drug releasing performance. The integrated MnOx NPs can disintegrate in mild acidic and reduction environment to realize the highly efficient pH-responsive and reduction-triggered T1-weighted magnetic resonance imaging (MRI). Superparamagnetic Fe3O4 NPs can not only function as the T2-weighted contrast agents for MRI, but also response to the external magnetic field for magnetic hyperthermia against cancer. Importantly, the constructed biocompatible GO-based nanoplatform can inhibit the metastasis of cancer cells by downregulating the expression of metastasis-related proteins, and anticancer drug-loaded carrier can significantly reverse the multidrug resistance (MDR) of cancer cells. A triple-functional biocompatible stimuli-responsive nanosystem based on the functionalized nanographene oxides is developed by a novel and efficient double redox strategy. This elaborately designed nanographene oxide-based nanoplatform exhibits the unique triple stimuli-responsivenesses for biomedical engineering, including pH-responsive drug release to inhibit the metastasis and reverse the multidrug resistance of cancer cells, pH-/redox-responsive magnetic resonance imaging and magnetic field-responsive hyperthermia of cancer.",

keywords = "MRI, cancer therapy, graphene oxide, hyperthermia, stimuli-responsiveness",

author = "Yu Chen and Pengfei Xu and Zhu Shu and Meiying Wu and Lianzhou Wang and Shengjian Zhang and Yuanyi Zheng and Hangrong Chen and Jin Wang and Yaping Li and Jianlin Shi",

year = "2014",

month = jul,

day = "23",

doi = "10.1002/adfm.201400221",

language = "英语",

volume = "24",

pages = "4386--4396",

journal = "Advanced Functional Materials",

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TY - JOUR

T1 - Multifunctional graphene oxide-based triple stimuli-responsive nanotheranostics

AU - Chen, Yu

AU - Xu, Pengfei

AU - Shu, Zhu

AU - Wu, Meiying

AU - Wang, Lianzhou

AU - Zhang, Shengjian

AU - Zheng, Yuanyi

AU - Chen, Hangrong

AU - Wang, Jin

AU - Li, Yaping

AU - Shi, Jianlin

PY - 2014/7/23

Y1 - 2014/7/23

N2 - Construction of multifunctional stimuli-responsive nanosystems intelligently responsive to inner physiological and/or external irradiations based on nanobiotechnology can enable the on-demand drug release and improved diagnostic imaging to mitigate the side-effects of anticancer drugs and enhance the diagnostic/therapeutic outcome simultaneously. Here, a triple-functional stimuli-responsive nanosystem based on the co-integration of superparamagnetic Fe3O4 and paramagnetic MnOx nanoparticles (NPs) onto exfoliated graphene oxide (GO) nanosheets by a novel and efficient double redox strategy (DRS) is reported. Aromatic anticancer drug molecules can interact with GO nanosheets through supramolecular π stacking to achieve high drug loading capacity and pH-responsive drug releasing performance. The integrated MnOx NPs can disintegrate in mild acidic and reduction environment to realize the highly efficient pH-responsive and reduction-triggered T1-weighted magnetic resonance imaging (MRI). Superparamagnetic Fe3O4 NPs can not only function as the T2-weighted contrast agents for MRI, but also response to the external magnetic field for magnetic hyperthermia against cancer. Importantly, the constructed biocompatible GO-based nanoplatform can inhibit the metastasis of cancer cells by downregulating the expression of metastasis-related proteins, and anticancer drug-loaded carrier can significantly reverse the multidrug resistance (MDR) of cancer cells. A triple-functional biocompatible stimuli-responsive nanosystem based on the functionalized nanographene oxides is developed by a novel and efficient double redox strategy. This elaborately designed nanographene oxide-based nanoplatform exhibits the unique triple stimuli-responsivenesses for biomedical engineering, including pH-responsive drug release to inhibit the metastasis and reverse the multidrug resistance of cancer cells, pH-/redox-responsive magnetic resonance imaging and magnetic field-responsive hyperthermia of cancer.

AB - Construction of multifunctional stimuli-responsive nanosystems intelligently responsive to inner physiological and/or external irradiations based on nanobiotechnology can enable the on-demand drug release and improved diagnostic imaging to mitigate the side-effects of anticancer drugs and enhance the diagnostic/therapeutic outcome simultaneously. Here, a triple-functional stimuli-responsive nanosystem based on the co-integration of superparamagnetic Fe3O4 and paramagnetic MnOx nanoparticles (NPs) onto exfoliated graphene oxide (GO) nanosheets by a novel and efficient double redox strategy (DRS) is reported. Aromatic anticancer drug molecules can interact with GO nanosheets through supramolecular π stacking to achieve high drug loading capacity and pH-responsive drug releasing performance. The integrated MnOx NPs can disintegrate in mild acidic and reduction environment to realize the highly efficient pH-responsive and reduction-triggered T1-weighted magnetic resonance imaging (MRI). Superparamagnetic Fe3O4 NPs can not only function as the T2-weighted contrast agents for MRI, but also response to the external magnetic field for magnetic hyperthermia against cancer. Importantly, the constructed biocompatible GO-based nanoplatform can inhibit the metastasis of cancer cells by downregulating the expression of metastasis-related proteins, and anticancer drug-loaded carrier can significantly reverse the multidrug resistance (MDR) of cancer cells. A triple-functional biocompatible stimuli-responsive nanosystem based on the functionalized nanographene oxides is developed by a novel and efficient double redox strategy. This elaborately designed nanographene oxide-based nanoplatform exhibits the unique triple stimuli-responsivenesses for biomedical engineering, including pH-responsive drug release to inhibit the metastasis and reverse the multidrug resistance of cancer cells, pH-/redox-responsive magnetic resonance imaging and magnetic field-responsive hyperthermia of cancer.

KW - MRI

KW - cancer therapy

KW - graphene oxide

KW - hyperthermia

KW - stimuli-responsiveness

UR - https://www.scopus.com/pages/publications/84904601831

U2 - 10.1002/adfm.201400221

DO - 10.1002/adfm.201400221

M3 - 文章

AN - SCOPUS:84904601831

SN - 1616-301X

VL - 24

SP - 4386

EP - 4396

JO - Advanced Functional Materials

JF - Advanced Functional Materials

IS - 28

ER -

Multifunctional graphene oxide-based triple stimuli-responsive nanotheranostics

Abstract

Keywords

UN SDGs

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