Multicatalyst System Realized Asymmetric Tandem Reactions

Multicatalyst system realized asymmetric tandem reactions (MSRATR) refer to the synthetic strategy of modular combination of several reactions, with at least one catalytic asymmetric step, into one synthetic operation with minimum workup or change in conditions. Despite the attractive advantages of MSRATR, the development of which becomes feasible till three pillars that modern asymmetric catalysis is built on, namely asymmetric metal catalysis, biocatalysis, and organocatalysis, are well studied and understood, with a variety of activation models discovered and matured. This chapter summarizes the advances in the MSRATR and classifies it by the types of catalyst combinations. Generally, MSRATRs are classified into two major categories namely: homocombination and heterocombination. The former includes multiple metal catalysis, multiple organocatalysis, and multiple enzyme catalysis, while the latter includes the combined metal and organocatalysts, and the combination of enzymes and other catalysts.