Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy

Yannan Yang; Yao Lu; Prasanna Lakshmi Abbaraju; Jun Zhang; Min Zhang; Guangya Xiang; Chengzhong Yu

doi:10.1002/anie.201701550

Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy

Yannan Yang
, Yao Lu
, Prasanna Lakshmi Abbaraju
, Jun Zhang
, Min Zhang
, Guangya Xiang^*
, Chengzhong Yu

^*Corresponding author for this work

University of Queensland
Huazhong University of Science and Technology

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.

Original language	English
Pages (from-to)	8446-8450
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	56
Issue number	29
DOIs	https://doi.org/10.1002/anie.201701550
State	Published - 10 Jul 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

adjuvants
antitumor activity
immunotherapy
multi-shelled materials
organosilica

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10.1002/anie.201701550

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title = "Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy",

abstract = "Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.",

keywords = "adjuvants, antitumor activity, immunotherapy, multi-shelled materials, organosilica",

author = "Yannan Yang and Yao Lu and Abbaraju, \{Prasanna Lakshmi\} and Jun Zhang and Min Zhang and Guangya Xiang and Chengzhong Yu",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2017",

month = jul,

day = "10",

doi = "10.1002/anie.201701550",

language = "英语",

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T1 - Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres

T2 - Roles of Composition and Architecture in Cancer Immunotherapy

AU - Yang, Yannan

AU - Lu, Yao

AU - Abbaraju, Prasanna Lakshmi

AU - Zhang, Jun

AU - Zhang, Min

AU - Xiang, Guangya

AU - Yu, Chengzhong

PY - 2017/7/10

Y1 - 2017/7/10

N2 - Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.

AB - Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.

KW - adjuvants

KW - antitumor activity

KW - immunotherapy

KW - multi-shelled materials

KW - organosilica

UR - https://www.scopus.com/pages/publications/85019004897

U2 - 10.1002/anie.201701550

DO - 10.1002/anie.201701550

M3 - 文章

C2 - 28467690

AN - SCOPUS:85019004897

SN - 1433-7851

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EP - 8450

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 29

ER -

Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy

Abstract

UN SDGs

Keywords

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