TY - GEN
T1 - Muiti-functionalizations of hollow mesoporous silica nanospheres and their HIFU application
AU - Chen, H. R.
AU - Wang, X.
AU - Zhang, K.
AU - Chen, Y.
AU - Shi, J. L.
PY - 2013
Y1 - 2013
N2 - High intensity focused ultrasound (HIFU), as a representative non-invasive therapeutic mode, has attracted extensive attentions among biological and medical researchers. In this paper, we focused on constructing multifunctional hollow mesoporous silica nanospheres (HMSNs) as innovative and efficient theranostic/synergistic agents to explore them in HIFU application. First, Au NPs-coated, PFH-encapsulated and PEGylated mesoporous silica nanocapsules-based nano-platform has been constructed as a contrast-intensified ultrasound (US) imaging agent and simultaneously an intensified US-guided HIFU enhancement agent. Besides, a novel temperature-responsive theranostic system is designed and investigated, using L-menthol as phase-change medium, which enables the substantial co-entrapment of hydrophilic and hydrophobic drugs and their temperature-responsive release, and more importantly, also can be used as both the US contrast agents and HIFU therapeutic enhancement agents.
AB - High intensity focused ultrasound (HIFU), as a representative non-invasive therapeutic mode, has attracted extensive attentions among biological and medical researchers. In this paper, we focused on constructing multifunctional hollow mesoporous silica nanospheres (HMSNs) as innovative and efficient theranostic/synergistic agents to explore them in HIFU application. First, Au NPs-coated, PFH-encapsulated and PEGylated mesoporous silica nanocapsules-based nano-platform has been constructed as a contrast-intensified ultrasound (US) imaging agent and simultaneously an intensified US-guided HIFU enhancement agent. Besides, a novel temperature-responsive theranostic system is designed and investigated, using L-menthol as phase-change medium, which enables the substantial co-entrapment of hydrophilic and hydrophobic drugs and their temperature-responsive release, and more importantly, also can be used as both the US contrast agents and HIFU therapeutic enhancement agents.
KW - High intensity focused ultrasound
KW - Hollow silica
KW - Mesoporous
KW - Multifunctionalization
KW - Ultrasound contrast
UR - https://www.scopus.com/pages/publications/84881095478
M3 - 会议稿件
AN - SCOPUS:84881095478
SN - 9781482205862
T3 - Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
SP - 206
EP - 209
BT - Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
T2 - Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Y2 - 12 May 2013 through 16 May 2013
ER -