Molecular photoacoustic imaging using gold nanoparticles as a contrast agent

Chulhong Kim; Eun Chul Cho; Jingyi Chen; Kwang Hyun Song; Leslie Au; Christopher P. Favazza; Qiang Zhang; Claire M. Cobley; Younan Xia; Lihong V. Wang

doi:10.1117/12.843549

Molecular photoacoustic imaging using gold nanoparticles as a contrast agent

Chulhong Kim
, Eun Chul Cho
, Jingyi Chen
, Kwang Hyun Song
, Leslie Au
, Christopher P. Favazza
, Qiang Zhang
, Claire M. Cobley
, Younan Xia
, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Gold nanoparticles have received much attention due to their potential diagnostic and therapeutic applications. Gold nanoparticles are attractive in many biomedical applications because of their biocompatibility, easily modifiable surfaces for targeting, lack of heavy metal toxicity, wide range of sizes (35-100 nm), tunable plasmonic resonance peak, encapsulated site-specific drug delivery, and strong optical absorption in the near-infrared regime. Specifically, due to their strong optical absorption, gold nanoparticles have been used as a contrast agent for molecular photoacoustic (PA) imaging of tumor. The plasmonic resonance peak of the gold nanocages (AuNCs) was tuned to the near-infrared region, and the ratio of the absorption cross-section to the extinction cross-section was approximately ~70%, as measured by PA sensing. We used PEGylated gold nanocages (PEG-AuNCs) as a passive targeting contrast agent on melanomas. After 6-h intravenous injection of PEG-AuNCs, PA amplitude was increased by ∼14 %. These results strongly suggest PA imaging paired with AuNCs is a promising diagnostic tool for early cancer detection.

Original language	English
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2010
Publisher	SPIE
ISBN (Print)	9780819479600
DOIs	https://doi.org/10.1117/12.843549
State	Published - 11 Feb 2011
Externally published	Yes
Event	Photons Plus Ultrasound: Imaging and Sensing 2010 - San Francisco, CA, United States Duration: 24 Jan 2010 → 26 Jan 2010

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7564
ISSN (Print)	1605-7422

Conference

Conference	Photons Plus Ultrasound: Imaging and Sensing 2010
Country/Territory	United States
City	San Francisco, CA
Period	24/01/10 → 26/01/10

Keywords

B16 melanoma
Gold nanoparticles
Molecular imaging
Photoacoustic tomography

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.843549

Cite this

Kim, C., Cho, E. C., Chen, J., Song, K. H., Au, L., Favazza, C. P., Zhang, Q., Cobley, C. M., Xia, Y., & Wang, L. V. (2011). Molecular photoacoustic imaging using gold nanoparticles as a contrast agent. In Photons Plus Ultrasound: Imaging and Sensing 2010 Article 75641V (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7564). SPIE. https://doi.org/10.1117/12.843549

@inproceedings{d8eb65535684411ca885c8bae31c303e,

title = "Molecular photoacoustic imaging using gold nanoparticles as a contrast agent",

abstract = "Gold nanoparticles have received much attention due to their potential diagnostic and therapeutic applications. Gold nanoparticles are attractive in many biomedical applications because of their biocompatibility, easily modifiable surfaces for targeting, lack of heavy metal toxicity, wide range of sizes (35-100 nm), tunable plasmonic resonance peak, encapsulated site-specific drug delivery, and strong optical absorption in the near-infrared regime. Specifically, due to their strong optical absorption, gold nanoparticles have been used as a contrast agent for molecular photoacoustic (PA) imaging of tumor. The plasmonic resonance peak of the gold nanocages (AuNCs) was tuned to the near-infrared region, and the ratio of the absorption cross-section to the extinction cross-section was approximately \textasciitilde{}70\%, as measured by PA sensing. We used PEGylated gold nanocages (PEG-AuNCs) as a passive targeting contrast agent on melanomas. After 6-h intravenous injection of PEG-AuNCs, PA amplitude was increased by ∼14 \%. These results strongly suggest PA imaging paired with AuNCs is a promising diagnostic tool for early cancer detection.",

keywords = "B16 melanoma, Gold nanoparticles, Molecular imaging, Photoacoustic tomography",

author = "Chulhong Kim and Cho, \{Eun Chul\} and Jingyi Chen and Song, \{Kwang Hyun\} and Leslie Au and Favazza, \{Christopher P.\} and Qiang Zhang and Cobley, \{Claire M.\} and Younan Xia and Wang, \{Lihong V.\}",

year = "2011",

month = feb,

day = "11",

doi = "10.1117/12.843549",

language = "英语",

isbn = "9780819479600",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

booktitle = "Photons Plus Ultrasound",

address = "美国",

note = "Photons Plus Ultrasound: Imaging and Sensing 2010 ; Conference date: 24-01-2010 Through 26-01-2010",

}

Kim, C, Cho, EC, Chen, J, Song, KH, Au, L, Favazza, CP, Zhang, Q, Cobley, CM, Xia, Y & Wang, LV 2011, Molecular photoacoustic imaging using gold nanoparticles as a contrast agent. in Photons Plus Ultrasound: Imaging and Sensing 2010., 75641V, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 7564, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2010, San Francisco, CA, United States, 24/01/10. https://doi.org/10.1117/12.843549

Molecular photoacoustic imaging using gold nanoparticles as a contrast agent. / Kim, Chulhong; Cho, Eun Chul; Chen, Jingyi et al.
Photons Plus Ultrasound: Imaging and Sensing 2010. SPIE, 2011. 75641V (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7564).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Molecular photoacoustic imaging using gold nanoparticles as a contrast agent

AU - Kim, Chulhong

AU - Cho, Eun Chul

AU - Chen, Jingyi

AU - Song, Kwang Hyun

AU - Au, Leslie

AU - Favazza, Christopher P.

AU - Zhang, Qiang

AU - Cobley, Claire M.

AU - Xia, Younan

AU - Wang, Lihong V.

PY - 2011/2/11

Y1 - 2011/2/11

N2 - Gold nanoparticles have received much attention due to their potential diagnostic and therapeutic applications. Gold nanoparticles are attractive in many biomedical applications because of their biocompatibility, easily modifiable surfaces for targeting, lack of heavy metal toxicity, wide range of sizes (35-100 nm), tunable plasmonic resonance peak, encapsulated site-specific drug delivery, and strong optical absorption in the near-infrared regime. Specifically, due to their strong optical absorption, gold nanoparticles have been used as a contrast agent for molecular photoacoustic (PA) imaging of tumor. The plasmonic resonance peak of the gold nanocages (AuNCs) was tuned to the near-infrared region, and the ratio of the absorption cross-section to the extinction cross-section was approximately ~70%, as measured by PA sensing. We used PEGylated gold nanocages (PEG-AuNCs) as a passive targeting contrast agent on melanomas. After 6-h intravenous injection of PEG-AuNCs, PA amplitude was increased by ∼14 %. These results strongly suggest PA imaging paired with AuNCs is a promising diagnostic tool for early cancer detection.

AB - Gold nanoparticles have received much attention due to their potential diagnostic and therapeutic applications. Gold nanoparticles are attractive in many biomedical applications because of their biocompatibility, easily modifiable surfaces for targeting, lack of heavy metal toxicity, wide range of sizes (35-100 nm), tunable plasmonic resonance peak, encapsulated site-specific drug delivery, and strong optical absorption in the near-infrared regime. Specifically, due to their strong optical absorption, gold nanoparticles have been used as a contrast agent for molecular photoacoustic (PA) imaging of tumor. The plasmonic resonance peak of the gold nanocages (AuNCs) was tuned to the near-infrared region, and the ratio of the absorption cross-section to the extinction cross-section was approximately ~70%, as measured by PA sensing. We used PEGylated gold nanocages (PEG-AuNCs) as a passive targeting contrast agent on melanomas. After 6-h intravenous injection of PEG-AuNCs, PA amplitude was increased by ∼14 %. These results strongly suggest PA imaging paired with AuNCs is a promising diagnostic tool for early cancer detection.

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KW - Photoacoustic tomography

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M3 - 会议稿件

AN - SCOPUS:77951532249

SN - 9780819479600

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photons Plus Ultrasound

PB - SPIE

T2 - Photons Plus Ultrasound: Imaging and Sensing 2010

Y2 - 24 January 2010 through 26 January 2010

ER -

Molecular photoacoustic imaging using gold nanoparticles as a contrast agent

Abstract

Publication series

Conference

Keywords

UN SDGs

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