Molecular mechanism for memory storage

Objective: To further understand the mechanism and process of memory storage on the basis of summarizing the survey about molecular mechanism on memory storage at home and abroad. Data sources: An online search of Medline database was applied with the keywords of "memory, storage, mechanism" to identify related articles published in English from January 1994 to April 2004. Meanwhile, Chinese articles published between January 1994 and April 2004 were identified on China National Knowledge Infrastructure (CHKI), and the keywords were "memory, storage, mechanism". Study selection: After preliminary search, the literatures related to memory and mechanism were selected, and then the obvious non-randomized trial studies were excluded. Finally the full-texts of the selected literatures were scanned. Data extraction: Totally 56 articles about the randomized or non-randomized trials related to memory, storage and mechanism were collected, and 13 were in accordance with the inclusive criteria, others were excluded. Data synthesis: Long-term depression and long-term potential are the essential problem concerning molecular on memory storage. Long-term depression has an important role of correcting operational wrongs. Long-term potential has closely associated with memory abilities, but the complete system of memory theory has not been established. Conclusion: The results of the current study indicate that the molecular mechanism of memory storage is complex, and still not clear, which needs the melting of other subjects for further study.