Molecular machines with bio-inspired mechanisms

  • Liang Zhang
  • , Vanesa Marcos
  • , David A. Leigh*
  • *Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

173 Scopus citations

Abstract

The widespread use of molecular-level motion in key natural processes suggests that great rewards could come from bridging the gap between the present generation of synthetic molecular machines—which by and large function as switches—and the machines of the macroscopic world, which utilize the synchronized behavior of integrated components to perform more sophisticated tasks than is possible with any individual switch. Should we try to make molecular machines of greater complexity by trying to mimic machines from the macroscopic world or instead apply unfamiliar (and no doubt have to discover or invent currently unknown) mechanisms utilized by biological machines? Here we try to answer that question by exploring some of the advances made to date using bio-inspired machine mechanisms.

Original languageEnglish
Pages (from-to)9397-9404
Number of pages8
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number38
DOIs
StatePublished - 18 Sep 2018

Keywords

  • Catenanes
  • Molecular machines
  • Molecular motors
  • Molecular robotics
  • Rotaxanes

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