TY - JOUR
T1 - Mitochondrial transfer/transplantation
T2 - an emerging therapeutic approach for multiple diseases
AU - Liu, Zonghan
AU - Sun, Yi
AU - Qi, Zhengtang
AU - Cao, Lu
AU - Ding, Shuzhe
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Mitochondria play a pivotal role in energy generation and cellular physiological processes. These organelles are highly dynamic, constantly changing their morphology, cellular location, and distribution in response to cellular stress. In recent years, the phenomenon of mitochondrial transfer has attracted significant attention and interest from biologists and medical investigators. Intercellular mitochondrial transfer occurs in different ways, including tunnelling nanotubes (TNTs), extracellular vesicles (EVs), and gap junction channels (GJCs). According to research on intercellular mitochondrial transfer in physiological and pathological environments, mitochondrial transfer hold great potential for maintaining body homeostasis and regulating pathological processes. Multiple research groups have developed artificial mitochondrial transfer/transplantation (AMT/T) methods that transfer healthy mitochondria into damaged cells and recover cellular function. This paper reviews intercellular spontaneous mitochondrial transfer modes, mechanisms, and the latest methods of AMT/T. Furthermore, potential application value and mechanism of AMT/T in disease treatment are also discussed.
AB - Mitochondria play a pivotal role in energy generation and cellular physiological processes. These organelles are highly dynamic, constantly changing their morphology, cellular location, and distribution in response to cellular stress. In recent years, the phenomenon of mitochondrial transfer has attracted significant attention and interest from biologists and medical investigators. Intercellular mitochondrial transfer occurs in different ways, including tunnelling nanotubes (TNTs), extracellular vesicles (EVs), and gap junction channels (GJCs). According to research on intercellular mitochondrial transfer in physiological and pathological environments, mitochondrial transfer hold great potential for maintaining body homeostasis and regulating pathological processes. Multiple research groups have developed artificial mitochondrial transfer/transplantation (AMT/T) methods that transfer healthy mitochondria into damaged cells and recover cellular function. This paper reviews intercellular spontaneous mitochondrial transfer modes, mechanisms, and the latest methods of AMT/T. Furthermore, potential application value and mechanism of AMT/T in disease treatment are also discussed.
KW - Ageing
KW - Cancer therapy
KW - Energy metabolism
KW - Mitochondrial transfer
KW - Mitochondrial transplantation
KW - Stem cell
KW - Tissue injury
KW - mtDNA mutations and deletions
UR - https://www.scopus.com/pages/publications/85130472758
U2 - 10.1186/s13578-022-00805-7
DO - 10.1186/s13578-022-00805-7
M3 - 文献综述
AN - SCOPUS:85130472758
SN - 2045-3701
VL - 12
JO - Cell and Bioscience
JF - Cell and Bioscience
IS - 1
M1 - 66
ER -
