Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus

Xiao Yang Mo; Wenli Ma; Yali Zhang; Haiquan Zhao; Yun Deng; Wuzhou Yuan; Yuequn Wang; Yongqin Li; Chuanbing Zhu; Mingyao Liu; Xiushan Wu

doi:10.1002/jmv.20942

Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus

Xiao Yang Mo, Wenli Ma, Yali Zhang, Haiquan Zhao, Yun Deng, Wuzhou Yuan, Yuequn Wang, Yongqin Li, Chuanbing Zhu, Mingyao Liu, Xiushan Wu

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Changes in mRNA expression levels of ECV304 cells infected with the wild-type rubella strain were analyzed using a microarray system representing 18,716 human genes. Four hundred eighty-seven genes exhibited differential expression levels; 456 of these genes were up-regulated while 31 genes were down-regulated. We identified 53 biological processes that were significantly relevant to the RV-infection. Among these biological processes, 52 were one-gene processes and one was a process involving five genes: IFNA21 (interferon, alpha 21), interferon stimulated exonuclease gene 20 kDa (ISG20), zinc finger protein 175 (ZNF175), tripartite motif-containing 22 (TRIM22), and MX2 [myxovirus (influenza virus) resistance 2 (mouse)]. Except for ZNF175, gene annotation indicated four of these genes encoded interferon or interferon-induced genes. These results suggest that genes relevant to interferon-regulated pathways may be involved in the pathogenesis of rubella.

Original language	English
Pages (from-to)	1783-1791
Number of pages	9
Journal	Journal of Medical Virology
Volume	79
Issue number	11
DOIs	https://doi.org/10.1002/jmv.20942
State	Published - Nov 2007
Externally published	Yes

Keywords

ECV304 cells
Microarray
Real-time RT-PCR
Rubella virus

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jmv.20942

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title = "Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus",

abstract = "Changes in mRNA expression levels of ECV304 cells infected with the wild-type rubella strain were analyzed using a microarray system representing 18,716 human genes. Four hundred eighty-seven genes exhibited differential expression levels; 456 of these genes were up-regulated while 31 genes were down-regulated. We identified 53 biological processes that were significantly relevant to the RV-infection. Among these biological processes, 52 were one-gene processes and one was a process involving five genes: IFNA21 (interferon, alpha 21), interferon stimulated exonuclease gene 20 kDa (ISG20), zinc finger protein 175 (ZNF175), tripartite motif-containing 22 (TRIM22), and MX2 [myxovirus (influenza virus) resistance 2 (mouse)]. Except for ZNF175, gene annotation indicated four of these genes encoded interferon or interferon-induced genes. These results suggest that genes relevant to interferon-regulated pathways may be involved in the pathogenesis of rubella.",

keywords = "ECV304 cells, Microarray, Real-time RT-PCR, Rubella virus",

author = "Mo, \{Xiao Yang\} and Wenli Ma and Yali Zhang and Haiquan Zhao and Yun Deng and Wuzhou Yuan and Yuequn Wang and Yongqin Li and Chuanbing Zhu and Mingyao Liu and Xiushan Wu",

year = "2007",

month = nov,

doi = "10.1002/jmv.20942",

language = "英语",

volume = "79",

pages = "1783--1791",

journal = "Journal of Medical Virology",

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TY - JOUR

T1 - Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus

AU - Mo, Xiao Yang

AU - Ma, Wenli

AU - Zhang, Yali

AU - Zhao, Haiquan

AU - Deng, Yun

AU - Yuan, Wuzhou

AU - Wang, Yuequn

AU - Li, Yongqin

AU - Zhu, Chuanbing

AU - Liu, Mingyao

AU - Wu, Xiushan

PY - 2007/11

Y1 - 2007/11

N2 - Changes in mRNA expression levels of ECV304 cells infected with the wild-type rubella strain were analyzed using a microarray system representing 18,716 human genes. Four hundred eighty-seven genes exhibited differential expression levels; 456 of these genes were up-regulated while 31 genes were down-regulated. We identified 53 biological processes that were significantly relevant to the RV-infection. Among these biological processes, 52 were one-gene processes and one was a process involving five genes: IFNA21 (interferon, alpha 21), interferon stimulated exonuclease gene 20 kDa (ISG20), zinc finger protein 175 (ZNF175), tripartite motif-containing 22 (TRIM22), and MX2 [myxovirus (influenza virus) resistance 2 (mouse)]. Except for ZNF175, gene annotation indicated four of these genes encoded interferon or interferon-induced genes. These results suggest that genes relevant to interferon-regulated pathways may be involved in the pathogenesis of rubella.

AB - Changes in mRNA expression levels of ECV304 cells infected with the wild-type rubella strain were analyzed using a microarray system representing 18,716 human genes. Four hundred eighty-seven genes exhibited differential expression levels; 456 of these genes were up-regulated while 31 genes were down-regulated. We identified 53 biological processes that were significantly relevant to the RV-infection. Among these biological processes, 52 were one-gene processes and one was a process involving five genes: IFNA21 (interferon, alpha 21), interferon stimulated exonuclease gene 20 kDa (ISG20), zinc finger protein 175 (ZNF175), tripartite motif-containing 22 (TRIM22), and MX2 [myxovirus (influenza virus) resistance 2 (mouse)]. Except for ZNF175, gene annotation indicated four of these genes encoded interferon or interferon-induced genes. These results suggest that genes relevant to interferon-regulated pathways may be involved in the pathogenesis of rubella.

KW - ECV304 cells

KW - Microarray

KW - Real-time RT-PCR

KW - Rubella virus

UR - https://www.scopus.com/pages/publications/34748906800

U2 - 10.1002/jmv.20942

DO - 10.1002/jmv.20942

M3 - 文章

C2 - 17854033

AN - SCOPUS:34748906800

SN - 0146-6615

VL - 79

SP - 1783

EP - 1791

JO - Journal of Medical Virology

JF - Journal of Medical Virology

IS - 11

ER -

Microarray analyses of differentially expressed human genes and biological processes in ECV304 cells infected with rubella virus

Abstract

Keywords

UN SDGs

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