Metallacages and Covalent Cages for Biological Imaging and Therapeutics

Wei Tao Dou; Chang Yin Yang; Lian Rui Hu; Bo Song; Tongxia Jin; Pei Pei Jia; Xuelei Ji; Feng Zheng; Hai Bo Yang; Lin Xu

doi:10.1021/acsmaterialslett.2c01147

Metallacages and Covalent Cages for Biological Imaging and Therapeutics

Wei Tao Dou, Chang Yin Yang, Lian Rui Hu, Bo Song, Tongxia Jin, Pei Pei Jia, Xuelei Ji, Feng Zheng, Hai Bo Yang, Lin Xu

East China Normal University

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

Due to their precise three-dimensional structures and tunable cavities, metallacages and covalent cages have been widely used in various fields, such as catalysis, separation, sensing, and biomedicine. As a result of the unique pattern of directed synthesis and modular assembly, cages can be modified in many different ways to construct stimuli-responsive cages for marker detection and imaging in biological applications. Additionally, imaging agents and drugs can be loaded into the unique cavity of the cages to achieve precise disease diagnosis and treatment. This Review summarizes recent advances in metallacages and covalent cages in biological applications and presents their representative examples in imaging and therapeutics. The problems and future development directions of cages in biological applications are emphasized, which may provide clear guidance for the design and application of precise and controllable biological diagnostic reagents.

Original language	English
Pages (from-to)	1061-1082
Number of pages	22
Journal	ACS Materials Letters
Volume	5
Issue number	4
DOIs	https://doi.org/10.1021/acsmaterialslett.2c01147
State	Published - 3 Apr 2023

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10.1021/acsmaterialslett.2c01147

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title = "Metallacages and Covalent Cages for Biological Imaging and Therapeutics",

abstract = "Due to their precise three-dimensional structures and tunable cavities, metallacages and covalent cages have been widely used in various fields, such as catalysis, separation, sensing, and biomedicine. As a result of the unique pattern of directed synthesis and modular assembly, cages can be modified in many different ways to construct stimuli-responsive cages for marker detection and imaging in biological applications. Additionally, imaging agents and drugs can be loaded into the unique cavity of the cages to achieve precise disease diagnosis and treatment. This Review summarizes recent advances in metallacages and covalent cages in biological applications and presents their representative examples in imaging and therapeutics. The problems and future development directions of cages in biological applications are emphasized, which may provide clear guidance for the design and application of precise and controllable biological diagnostic reagents.",

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doi = "10.1021/acsmaterialslett.2c01147",

language = "英语",

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T1 - Metallacages and Covalent Cages for Biological Imaging and Therapeutics

AU - Dou, Wei Tao

AU - Yang, Chang Yin

AU - Hu, Lian Rui

AU - Song, Bo

AU - Jin, Tongxia

AU - Jia, Pei Pei

AU - Ji, Xuelei

AU - Zheng, Feng

AU - Yang, Hai Bo

AU - Xu, Lin

PY - 2023/4/3

Y1 - 2023/4/3

N2 - Due to their precise three-dimensional structures and tunable cavities, metallacages and covalent cages have been widely used in various fields, such as catalysis, separation, sensing, and biomedicine. As a result of the unique pattern of directed synthesis and modular assembly, cages can be modified in many different ways to construct stimuli-responsive cages for marker detection and imaging in biological applications. Additionally, imaging agents and drugs can be loaded into the unique cavity of the cages to achieve precise disease diagnosis and treatment. This Review summarizes recent advances in metallacages and covalent cages in biological applications and presents their representative examples in imaging and therapeutics. The problems and future development directions of cages in biological applications are emphasized, which may provide clear guidance for the design and application of precise and controllable biological diagnostic reagents.

AB - Due to their precise three-dimensional structures and tunable cavities, metallacages and covalent cages have been widely used in various fields, such as catalysis, separation, sensing, and biomedicine. As a result of the unique pattern of directed synthesis and modular assembly, cages can be modified in many different ways to construct stimuli-responsive cages for marker detection and imaging in biological applications. Additionally, imaging agents and drugs can be loaded into the unique cavity of the cages to achieve precise disease diagnosis and treatment. This Review summarizes recent advances in metallacages and covalent cages in biological applications and presents their representative examples in imaging and therapeutics. The problems and future development directions of cages in biological applications are emphasized, which may provide clear guidance for the design and application of precise and controllable biological diagnostic reagents.

UR - https://www.scopus.com/pages/publications/85149808637

U2 - 10.1021/acsmaterialslett.2c01147

DO - 10.1021/acsmaterialslett.2c01147

M3 - 文献综述

AN - SCOPUS:85149808637

SN - 2639-4979

VL - 5

SP - 1061

EP - 1082

JO - ACS Materials Letters

JF - ACS Materials Letters

IS - 4

ER -

Metallacages and Covalent Cages for Biological Imaging and Therapeutics

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