Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum

Chang Lei; Chun Xu; Owen Noonan; Anand Kumar Meka; Long Zhang; Amanda Nouwens; Chengzhong Yu

doi:10.1039/c5cc04458h

Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum

Chang Lei
, Chun Xu
, Owen Noonan
, Anand Kumar Meka
, Long Zhang
, Amanda Nouwens
, Chengzhong Yu^*

^*Corresponding author for this work

University of Queensland

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A novel mesoporous material modified with both insulin-binding-aptamers and hydrophobic methyl groups is synthesized. With rationally designed pore structures and surface chemistry, this material is applied in sample pre-treatment for ELISA, and enables the quantification (0.25-5 pg ml^-1) of insulin in serum, 30-fold enhancement of the limit-of-detection compared to the commercial ELISA kit.

Original language	English
Pages (from-to)	13642-13645
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	71
DOIs	https://doi.org/10.1039/c5cc04458h
State	Published - 17 Jul 2015
Externally published	Yes

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10.1039/c5cc04458h

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title = "Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum",

abstract = "A novel mesoporous material modified with both insulin-binding-aptamers and hydrophobic methyl groups is synthesized. With rationally designed pore structures and surface chemistry, this material is applied in sample pre-treatment for ELISA, and enables the quantification (0.25-5 pg ml-1) of insulin in serum, 30-fold enhancement of the limit-of-detection compared to the commercial ELISA kit.",

author = "Chang Lei and Chun Xu and Owen Noonan and Meka, \{Anand Kumar\} and Long Zhang and Amanda Nouwens and Chengzhong Yu",

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T1 - Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum

AU - Lei, Chang

AU - Xu, Chun

AU - Noonan, Owen

AU - Meka, Anand Kumar

AU - Zhang, Long

AU - Nouwens, Amanda

AU - Yu, Chengzhong

PY - 2015/7/17

Y1 - 2015/7/17

N2 - A novel mesoporous material modified with both insulin-binding-aptamers and hydrophobic methyl groups is synthesized. With rationally designed pore structures and surface chemistry, this material is applied in sample pre-treatment for ELISA, and enables the quantification (0.25-5 pg ml-1) of insulin in serum, 30-fold enhancement of the limit-of-detection compared to the commercial ELISA kit.

AB - A novel mesoporous material modified with both insulin-binding-aptamers and hydrophobic methyl groups is synthesized. With rationally designed pore structures and surface chemistry, this material is applied in sample pre-treatment for ELISA, and enables the quantification (0.25-5 pg ml-1) of insulin in serum, 30-fold enhancement of the limit-of-detection compared to the commercial ELISA kit.

UR - https://www.scopus.com/pages/publications/84939863816

U2 - 10.1039/c5cc04458h

DO - 10.1039/c5cc04458h

M3 - 文章

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AN - SCOPUS:84939863816

SN - 1359-7345

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SP - 13642

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JO - Chemical Communications

JF - Chemical Communications

IS - 71

ER -

Mesoporous materials modified by aptamers and hydrophobic groups assist ultra-sensitive insulin detection in serum

Abstract

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