Mesoporous carbon@silicon-silica nanotheranostics for synchronous delivery of insoluble drugs and luminescence imaging

Qianjun He; Ming Ma; Chenyang Wei; Jianlin Shi

doi:10.1016/j.biomaterials.2012.02.056

Mesoporous carbon@silicon-silica nanotheranostics for synchronous delivery of insoluble drugs and luminescence imaging

Qianjun He, Ming Ma, Chenyang Wei, Jianlin Shi

CAS - Shanghai Institute of Ceramics

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

A hierarchical theranostic nanostructure with carbon and Si nanocrystals respectively encapsulated in the mesopores and within the framework of mesoporous silica nanoparticles (CS-MSNs) was constructed by a bottom-up self-assembly strategy combining an . in situ one-step carbonization/crystallization approach. CS-MSNs exhibited narrow size distribution, high payload of insoluble drugs and unique NIR-to-Vis luminescence imaging feature. The bio-conjugated CS-MSNs with a PEGylated phospholipid compound and hyaluronic acid showed excellent dispersivity and could specifically target cancer cells overexpressing CD44, deliver insoluble drugs into these cells and consequently kill them effectively, and also fluorescently image them simultaneously in a unique and attractive NIR-to-Vis luminescence imaging fashion, providing a promising opportunity for cancer theranostics.

Original language	English
Pages (from-to)	4392-4402
Number of pages	11
Journal	Biomaterials
Volume	33
Issue number	17
DOIs	https://doi.org/10.1016/j.biomaterials.2012.02.056
State	Published - Jun 2012
Externally published	Yes

Keywords

Drug delivery
Hierarchical nanostructures
Luminescence imaging
Mesoporous silica
Nanoparticle
Theranostic nanomedicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.biomaterials.2012.02.056

Cite this

@article{4ad3e8a90ea948fcb54dd25380659781,

title = "Mesoporous carbon@silicon-silica nanotheranostics for synchronous delivery of insoluble drugs and luminescence imaging",

abstract = "A hierarchical theranostic nanostructure with carbon and Si nanocrystals respectively encapsulated in the mesopores and within the framework of mesoporous silica nanoparticles (CS-MSNs) was constructed by a bottom-up self-assembly strategy combining an . in situ one-step carbonization/crystallization approach. CS-MSNs exhibited narrow size distribution, high payload of insoluble drugs and unique NIR-to-Vis luminescence imaging feature. The bio-conjugated CS-MSNs with a PEGylated phospholipid compound and hyaluronic acid showed excellent dispersivity and could specifically target cancer cells overexpressing CD44, deliver insoluble drugs into these cells and consequently kill them effectively, and also fluorescently image them simultaneously in a unique and attractive NIR-to-Vis luminescence imaging fashion, providing a promising opportunity for cancer theranostics.",

keywords = "Drug delivery, Hierarchical nanostructures, Luminescence imaging, Mesoporous silica, Nanoparticle, Theranostic nanomedicine",

author = "Qianjun He and Ming Ma and Chenyang Wei and Jianlin Shi",

year = "2012",

month = jun,

doi = "10.1016/j.biomaterials.2012.02.056",

language = "英语",

volume = "33",

pages = "4392--4402",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier Ltd",

number = "17",

}

TY - JOUR

T1 - Mesoporous carbon@silicon-silica nanotheranostics for synchronous delivery of insoluble drugs and luminescence imaging

AU - He, Qianjun

AU - Ma, Ming

AU - Wei, Chenyang

AU - Shi, Jianlin

PY - 2012/6

Y1 - 2012/6

N2 - A hierarchical theranostic nanostructure with carbon and Si nanocrystals respectively encapsulated in the mesopores and within the framework of mesoporous silica nanoparticles (CS-MSNs) was constructed by a bottom-up self-assembly strategy combining an . in situ one-step carbonization/crystallization approach. CS-MSNs exhibited narrow size distribution, high payload of insoluble drugs and unique NIR-to-Vis luminescence imaging feature. The bio-conjugated CS-MSNs with a PEGylated phospholipid compound and hyaluronic acid showed excellent dispersivity and could specifically target cancer cells overexpressing CD44, deliver insoluble drugs into these cells and consequently kill them effectively, and also fluorescently image them simultaneously in a unique and attractive NIR-to-Vis luminescence imaging fashion, providing a promising opportunity for cancer theranostics.

AB - A hierarchical theranostic nanostructure with carbon and Si nanocrystals respectively encapsulated in the mesopores and within the framework of mesoporous silica nanoparticles (CS-MSNs) was constructed by a bottom-up self-assembly strategy combining an . in situ one-step carbonization/crystallization approach. CS-MSNs exhibited narrow size distribution, high payload of insoluble drugs and unique NIR-to-Vis luminescence imaging feature. The bio-conjugated CS-MSNs with a PEGylated phospholipid compound and hyaluronic acid showed excellent dispersivity and could specifically target cancer cells overexpressing CD44, deliver insoluble drugs into these cells and consequently kill them effectively, and also fluorescently image them simultaneously in a unique and attractive NIR-to-Vis luminescence imaging fashion, providing a promising opportunity for cancer theranostics.

KW - Drug delivery

KW - Hierarchical nanostructures

KW - Luminescence imaging

KW - Mesoporous silica

KW - Nanoparticle

KW - Theranostic nanomedicine

UR - https://www.scopus.com/pages/publications/84858865635

U2 - 10.1016/j.biomaterials.2012.02.056

DO - 10.1016/j.biomaterials.2012.02.056

M3 - 文章

C2 - 22425026

AN - SCOPUS:84858865635

SN - 0142-9612

VL - 33

SP - 4392

EP - 4402

JO - Biomaterials

JF - Biomaterials

IS - 17

ER -

Mesoporous carbon@silicon-silica nanotheranostics for synchronous delivery of insoluble drugs and luminescence imaging

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this