Mesoporous bioactive glasses for controlled drug release

Lingzhi Zhao; Xiaoxia Yan; Xufeng Zhou; Liang Zhou; Hongning Wang; Jiawei Tang; Chengzhong Yu

doi:10.1016/j.micromeso.2007.04.041

Mesoporous bioactive glasses for controlled drug release

Lingzhi Zhao
, Xiaoxia Yan
, Xufeng Zhou
, Liang Zhou
, Hongning Wang
, Jiawei Tang
, Chengzhong Yu^*

^*Corresponding author for this work

Fudan University

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

Mesoporous bioactive glasses (MBGs) with different compositions have been prepared and their drug release behaviors have been studied. Tetracycline (TC) is selected as the model drug. It is found that TC can be successfully loaded into the mesopores; and increasing the CaO content in MBG increases the loading ratio of TC/MBG. The drug release behaviors of MBGs are also strongly dependent on their composition. MBG 100S without CaO in the framework has a rapid drug release kinetics, while MBG 90S5C, 80S15C, and 70S25C show much slow release profiles and the release constant in the first 10 h decrease as the CaO content increases. However, the release constant of MBG 60S35C is abnormally larger compared to that of MBG 90S5C. The different drug release behaviors of MBGs have been explained by their difference in CaO composition.

Original language	English
Pages (from-to)	210-215
Number of pages	6
Journal	Microporous and Mesoporous Materials
Volume	109
Issue number	1-3
DOIs	https://doi.org/10.1016/j.micromeso.2007.04.041
State	Published - 1 Mar 2008
Externally published	Yes

Keywords

Controlled release
Drug delivery
Mesoporous bioactive glass
SBF (simulated body fluid)
Tetracycline

Access to Document

10.1016/j.micromeso.2007.04.041

Cite this

@article{67f89f7ec8b947fd948da7da09d03611,

title = "Mesoporous bioactive glasses for controlled drug release",

abstract = "Mesoporous bioactive glasses (MBGs) with different compositions have been prepared and their drug release behaviors have been studied. Tetracycline (TC) is selected as the model drug. It is found that TC can be successfully loaded into the mesopores; and increasing the CaO content in MBG increases the loading ratio of TC/MBG. The drug release behaviors of MBGs are also strongly dependent on their composition. MBG 100S without CaO in the framework has a rapid drug release kinetics, while MBG 90S5C, 80S15C, and 70S25C show much slow release profiles and the release constant in the first 10 h decrease as the CaO content increases. However, the release constant of MBG 60S35C is abnormally larger compared to that of MBG 90S5C. The different drug release behaviors of MBGs have been explained by their difference in CaO composition.",

keywords = "Controlled release, Drug delivery, Mesoporous bioactive glass, SBF (simulated body fluid), Tetracycline",

author = "Lingzhi Zhao and Xiaoxia Yan and Xufeng Zhou and Liang Zhou and Hongning Wang and Jiawei Tang and Chengzhong Yu",

year = "2008",

month = mar,

day = "1",

doi = "10.1016/j.micromeso.2007.04.041",

language = "英语",

volume = "109",

pages = "210--215",

journal = "Microporous and Mesoporous Materials",

issn = "1387-1811",

publisher = "Elsevier B.V.",

number = "1-3",

}

TY - JOUR

T1 - Mesoporous bioactive glasses for controlled drug release

AU - Zhao, Lingzhi

AU - Yan, Xiaoxia

AU - Zhou, Xufeng

AU - Zhou, Liang

AU - Wang, Hongning

AU - Tang, Jiawei

AU - Yu, Chengzhong

PY - 2008/3/1

Y1 - 2008/3/1

N2 - Mesoporous bioactive glasses (MBGs) with different compositions have been prepared and their drug release behaviors have been studied. Tetracycline (TC) is selected as the model drug. It is found that TC can be successfully loaded into the mesopores; and increasing the CaO content in MBG increases the loading ratio of TC/MBG. The drug release behaviors of MBGs are also strongly dependent on their composition. MBG 100S without CaO in the framework has a rapid drug release kinetics, while MBG 90S5C, 80S15C, and 70S25C show much slow release profiles and the release constant in the first 10 h decrease as the CaO content increases. However, the release constant of MBG 60S35C is abnormally larger compared to that of MBG 90S5C. The different drug release behaviors of MBGs have been explained by their difference in CaO composition.

AB - Mesoporous bioactive glasses (MBGs) with different compositions have been prepared and their drug release behaviors have been studied. Tetracycline (TC) is selected as the model drug. It is found that TC can be successfully loaded into the mesopores; and increasing the CaO content in MBG increases the loading ratio of TC/MBG. The drug release behaviors of MBGs are also strongly dependent on their composition. MBG 100S without CaO in the framework has a rapid drug release kinetics, while MBG 90S5C, 80S15C, and 70S25C show much slow release profiles and the release constant in the first 10 h decrease as the CaO content increases. However, the release constant of MBG 60S35C is abnormally larger compared to that of MBG 90S5C. The different drug release behaviors of MBGs have been explained by their difference in CaO composition.

KW - Controlled release

KW - Drug delivery

KW - Mesoporous bioactive glass

KW - SBF (simulated body fluid)

KW - Tetracycline

UR - https://www.scopus.com/pages/publications/37349011535

U2 - 10.1016/j.micromeso.2007.04.041

DO - 10.1016/j.micromeso.2007.04.041

M3 - 文章

AN - SCOPUS:37349011535

SN - 1387-1811

VL - 109

SP - 210

EP - 215

JO - Microporous and Mesoporous Materials

JF - Microporous and Mesoporous Materials

IS - 1-3

ER -

Mesoporous bioactive glasses for controlled drug release

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this