Mapping Novel Biomarkers of Liver Injury by Tissue Proteomic Analysis

Bo Yang; Jianan Zhang; Le Sun; Tingmei Huang; Yaqi Kong; Lei Li; Zhengwang Sun; Mengchen Yin; Xiaotao Li

doi:10.1021/acsomega.1c00152

Mapping Novel Biomarkers of Liver Injury by Tissue Proteomic Analysis

Bo Yang^*, Jianan Zhang, Le Sun, Tingmei Huang, Yaqi Kong, Lei Li, Zhengwang Sun^*, Mengchen Yin^*, Xiaotao Li^*

^*Corresponding author for this work

School of Life Sciences

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Liver damage is a dynamic process, and evaluation of liver injury degree is the key step in disease diagnosis. However, few common markers among different types of liver injury have been reported. Herein, we generated three liver injury mouse models, including Con A-induced, CCl4-injected, and subjected bile duct ligation mouse models, to simulate different types of liver damage in humans and then performed a label-free mass spectrometry to identify differentially expressed proteins in liver tissues. Interestingly, two proteins, G3BP and ABCC6, were conserved regulated in different liver injury models and are proposed to be biomarkers in liver injury, with G3BP upregulated and ABCC6 downregulated. Overall, our study identified two novel biomarkers of liver injury, and they might be used as potential drug targets of liver damage research studies.

Original language	English
Pages (from-to)	7127-7138
Number of pages	12
Journal	ACS Omega
Volume	6
Issue number	10
DOIs	https://doi.org/10.1021/acsomega.1c00152
State	Published - 16 Mar 2021

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10.1021/acsomega.1c00152

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title = "Mapping Novel Biomarkers of Liver Injury by Tissue Proteomic Analysis",

abstract = "Liver damage is a dynamic process, and evaluation of liver injury degree is the key step in disease diagnosis. However, few common markers among different types of liver injury have been reported. Herein, we generated three liver injury mouse models, including Con A-induced, CCl4-injected, and subjected bile duct ligation mouse models, to simulate different types of liver damage in humans and then performed a label-free mass spectrometry to identify differentially expressed proteins in liver tissues. Interestingly, two proteins, G3BP and ABCC6, were conserved regulated in different liver injury models and are proposed to be biomarkers in liver injury, with G3BP upregulated and ABCC6 downregulated. Overall, our study identified two novel biomarkers of liver injury, and they might be used as potential drug targets of liver damage research studies.",

author = "Bo Yang and Jianan Zhang and Le Sun and Tingmei Huang and Yaqi Kong and Lei Li and Zhengwang Sun and Mengchen Yin and Xiaotao Li",

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year = "2021",

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doi = "10.1021/acsomega.1c00152",

language = "英语",

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TY - JOUR

T1 - Mapping Novel Biomarkers of Liver Injury by Tissue Proteomic Analysis

AU - Yang, Bo

AU - Zhang, Jianan

AU - Sun, Le

AU - Huang, Tingmei

AU - Kong, Yaqi

AU - Li, Lei

AU - Sun, Zhengwang

AU - Yin, Mengchen

AU - Li, Xiaotao

PY - 2021/3/16

Y1 - 2021/3/16

N2 - Liver damage is a dynamic process, and evaluation of liver injury degree is the key step in disease diagnosis. However, few common markers among different types of liver injury have been reported. Herein, we generated three liver injury mouse models, including Con A-induced, CCl4-injected, and subjected bile duct ligation mouse models, to simulate different types of liver damage in humans and then performed a label-free mass spectrometry to identify differentially expressed proteins in liver tissues. Interestingly, two proteins, G3BP and ABCC6, were conserved regulated in different liver injury models and are proposed to be biomarkers in liver injury, with G3BP upregulated and ABCC6 downregulated. Overall, our study identified two novel biomarkers of liver injury, and they might be used as potential drug targets of liver damage research studies.

AB - Liver damage is a dynamic process, and evaluation of liver injury degree is the key step in disease diagnosis. However, few common markers among different types of liver injury have been reported. Herein, we generated three liver injury mouse models, including Con A-induced, CCl4-injected, and subjected bile duct ligation mouse models, to simulate different types of liver damage in humans and then performed a label-free mass spectrometry to identify differentially expressed proteins in liver tissues. Interestingly, two proteins, G3BP and ABCC6, were conserved regulated in different liver injury models and are proposed to be biomarkers in liver injury, with G3BP upregulated and ABCC6 downregulated. Overall, our study identified two novel biomarkers of liver injury, and they might be used as potential drug targets of liver damage research studies.

UR - https://www.scopus.com/pages/publications/85103422325

U2 - 10.1021/acsomega.1c00152

DO - 10.1021/acsomega.1c00152

M3 - 文章

AN - SCOPUS:85103422325

SN - 2470-1343

VL - 6

SP - 7127

EP - 7138

JO - ACS Omega

JF - ACS Omega

IS - 10

ER -

Mapping Novel Biomarkers of Liver Injury by Tissue Proteomic Analysis

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