Magnetic metal-organic frameworks: γ-Fe2O3@MOFs via confined in situ pyrolysis method for drug delivery

Yi Nan Wu; Meimei Zhou; Shu Li; Zehua Li; Jie Li; Baozhen Wu; Guangtao Li; Fengting Li; Xiaohong Guan

doi:10.1002/smll.201400362

Magnetic metal-organic frameworks: γ-Fe₂O₃@MOFs via confined in situ pyrolysis method for drug delivery

Yi Nan Wu
, Meimei Zhou
, Shu Li
, Zehua Li
, Jie Li
, Baozhen Wu
, Guangtao Li
, Fengting Li^*
, Xiaohong Guan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

206 Scopus citations

Abstract

A general one-step in situ pyrolysis route for the construction of metal-organic frameworks encapsulating superparamagnetic γ-Fe ₂O₃ NPs dispersed in the confined cavities of MOFs homogeneously is described. The integration of γ-Fe₂O ₃ NPs or clusters into MOFs can endow these porous materials with superparamagnetic element. By the combination of the thermal stability of MOFs and pyrolysis of metal triacetylacetonate complex at matched conditions, the porous structure of MOFs are well maintained while the size-induced superparamagnetic property of nano γ-Fe₂O₃ is obtained. As a proof of concept, both the γ- Fe₂O ₃@ZIF-8 and γ-Fe₂O₃@MIL-53(Al) were successfully prepared, and the latter was chosen to demonstrate its potential drug delivery as a magnetic MOF.

Original language	English
Pages (from-to)	2927-2936
Number of pages	10
Journal	Small
Volume	10
Issue number	14
DOIs	https://doi.org/10.1002/smll.201400362
State	Published - 23 Jul 2014
Externally published	Yes

Keywords

drug delivery
maghemite
metal-organic frameworks
nanoconfinement
superparamagnetism

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10.1002/smll.201400362

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title = "Magnetic metal-organic frameworks: γ-Fe2O3@MOFs via confined in situ pyrolysis method for drug delivery",

abstract = "A general one-step in situ pyrolysis route for the construction of metal-organic frameworks encapsulating superparamagnetic γ-Fe 2O3 NPs dispersed in the confined cavities of MOFs homogeneously is described. The integration of γ-Fe2O 3 NPs or clusters into MOFs can endow these porous materials with superparamagnetic element. By the combination of the thermal stability of MOFs and pyrolysis of metal triacetylacetonate complex at matched conditions, the porous structure of MOFs are well maintained while the size-induced superparamagnetic property of nano γ-Fe2O3 is obtained. As a proof of concept, both the γ- Fe2O 3@ZIF-8 and γ-Fe2O3@MIL-53(Al) were successfully prepared, and the latter was chosen to demonstrate its potential drug delivery as a magnetic MOF.",

keywords = "drug delivery, maghemite, metal-organic frameworks, nanoconfinement, superparamagnetism",

author = "Wu, \{Yi Nan\} and Meimei Zhou and Shu Li and Zehua Li and Jie Li and Baozhen Wu and Guangtao Li and Fengting Li and Xiaohong Guan",

year = "2014",

month = jul,

day = "23",

doi = "10.1002/smll.201400362",

language = "英语",

volume = "10",

pages = "2927--2936",

journal = "Small",

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TY - JOUR

T1 - Magnetic metal-organic frameworks

T2 - γ-Fe2O3@MOFs via confined in situ pyrolysis method for drug delivery

AU - Wu, Yi Nan

AU - Zhou, Meimei

AU - Li, Shu

AU - Li, Zehua

AU - Li, Jie

AU - Wu, Baozhen

AU - Li, Guangtao

AU - Li, Fengting

AU - Guan, Xiaohong

PY - 2014/7/23

Y1 - 2014/7/23

N2 - A general one-step in situ pyrolysis route for the construction of metal-organic frameworks encapsulating superparamagnetic γ-Fe 2O3 NPs dispersed in the confined cavities of MOFs homogeneously is described. The integration of γ-Fe2O 3 NPs or clusters into MOFs can endow these porous materials with superparamagnetic element. By the combination of the thermal stability of MOFs and pyrolysis of metal triacetylacetonate complex at matched conditions, the porous structure of MOFs are well maintained while the size-induced superparamagnetic property of nano γ-Fe2O3 is obtained. As a proof of concept, both the γ- Fe2O 3@ZIF-8 and γ-Fe2O3@MIL-53(Al) were successfully prepared, and the latter was chosen to demonstrate its potential drug delivery as a magnetic MOF.

AB - A general one-step in situ pyrolysis route for the construction of metal-organic frameworks encapsulating superparamagnetic γ-Fe 2O3 NPs dispersed in the confined cavities of MOFs homogeneously is described. The integration of γ-Fe2O 3 NPs or clusters into MOFs can endow these porous materials with superparamagnetic element. By the combination of the thermal stability of MOFs and pyrolysis of metal triacetylacetonate complex at matched conditions, the porous structure of MOFs are well maintained while the size-induced superparamagnetic property of nano γ-Fe2O3 is obtained. As a proof of concept, both the γ- Fe2O 3@ZIF-8 and γ-Fe2O3@MIL-53(Al) were successfully prepared, and the latter was chosen to demonstrate its potential drug delivery as a magnetic MOF.

KW - drug delivery

KW - maghemite

KW - metal-organic frameworks

KW - nanoconfinement

KW - superparamagnetism

UR - https://www.scopus.com/pages/publications/84904440665

U2 - 10.1002/smll.201400362

DO - 10.1002/smll.201400362

M3 - 文章

C2 - 24644065

AN - SCOPUS:84904440665

SN - 1613-6810

VL - 10

SP - 2927

EP - 2936

JO - Small

JF - Small

IS - 14

ER -

Magnetic metal-organic frameworks: γ-Fe₂O₃@MOFs via confined in situ pyrolysis method for drug delivery

Abstract

Keywords

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