TY - JOUR
T1 - Lock-in camera based heterodyne holography for ultrasound-modulated optical tomography inside dynamic scattering media
AU - Liu, Yan
AU - Shen, Yuecheng
AU - Ma, Cheng
AU - Shi, Junhui
AU - Wang, Lihong V.
N1 - Publisher Copyright:
© 2016 Author(s).
PY - 2016/6/6
Y1 - 2016/6/6
N2 - Ultrasound-modulated optical tomography (UOT) images optical contrast deep inside scattering media. Heterodyne holography based UOT is a promising technique that uses a camera for parallel speckle detection. In previous works, the speed of data acquisition was limited by the low frame rates of conventional cameras. In addition, when the signal-to-background ratio was low, these cameras wasted most of their bits representing an informationless background, resulting in extremely low efficiencies in the use of bits. Here, using a lock-in camera, we increase the bit efficiency and reduce the data transfer load by digitizing only the signal after rejecting the background. Moreover, compared with the conventional four-frame based amplitude measurement method, our single-frame method is more immune to speckle decorrelation. Using lock-in camera based UOT with an integration time of 286 μs, we imaged an absorptive object buried inside a dynamic scattering medium exhibiting a speckle correlation time (τc) as short as 26 μs. Since our method can tolerate speckle decorrelation faster than that found in living biological tissue (τc ∼ 100-1000 μs), it is promising for in vivo deep tissue non-invasive imaging.
AB - Ultrasound-modulated optical tomography (UOT) images optical contrast deep inside scattering media. Heterodyne holography based UOT is a promising technique that uses a camera for parallel speckle detection. In previous works, the speed of data acquisition was limited by the low frame rates of conventional cameras. In addition, when the signal-to-background ratio was low, these cameras wasted most of their bits representing an informationless background, resulting in extremely low efficiencies in the use of bits. Here, using a lock-in camera, we increase the bit efficiency and reduce the data transfer load by digitizing only the signal after rejecting the background. Moreover, compared with the conventional four-frame based amplitude measurement method, our single-frame method is more immune to speckle decorrelation. Using lock-in camera based UOT with an integration time of 286 μs, we imaged an absorptive object buried inside a dynamic scattering medium exhibiting a speckle correlation time (τc) as short as 26 μs. Since our method can tolerate speckle decorrelation faster than that found in living biological tissue (τc ∼ 100-1000 μs), it is promising for in vivo deep tissue non-invasive imaging.
UR - https://www.scopus.com/pages/publications/84974594004
U2 - 10.1063/1.4953630
DO - 10.1063/1.4953630
M3 - 文章
AN - SCOPUS:84974594004
SN - 0003-6951
VL - 108
JO - Applied Physics Letters
JF - Applied Physics Letters
IS - 23
M1 - 231106
ER -