Liquid chromatography-electrochemical detection for studying the effects of tetrahydrobiopterin on monoamine neurotransmitters in rat striatum

Wen Zhang; Wei Zhu; Haihong Xu; Fangli Wan; Jing Gu; Jingen Han; Litong Jin

doi:10.1360/04yb0133

Liquid chromatography-electrochemical detection for studying the effects of tetrahydrobiopterin on monoamine neurotransmitters in rat striatum

Wen Zhang
, Wei Zhu
, Haihong Xu
, Fangli Wan
, Jing Gu
, Jingen Han
, Litong Jin^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Tetrahydrobiopterin (BH ₄ ) is an essential co-factor in the biosynthesis of monoamine neurotransmitters. A nano-Pt/Pd modified electrode as the electrochemical detector (ED) for high-performance liquid chromatography (HPLC) coupled with microanalysis sampling, is used to explore the effect of administration of BH ₄ on the monoamine neurotransmitters in the rat striatum. The researches demonstrate that the contents of dopamine (DA), 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) increase significantly with the administration of BH ₄ . The pharmaceutical kinetics is carried out to research into the time course of BH ₄ effect on the concentration of monoamine neurotransmitters in rat striatum, which provides reliable data for pathology and pharmacology research on neuroscience.

Original language	English
Pages (from-to)	368-375
Number of pages	8
Journal	Science in China, Series B: Chemistry
Volume	48
Issue number	4
DOIs	https://doi.org/10.1360/04yb0133
State	Published - Aug 2005

Keywords

BH
ED
HPLC
Microanalysis sampling
Monoamine neurotransmitter
Nano-Pt/Pd modified electrode

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10.1360/04yb0133

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title = "Liquid chromatography-electrochemical detection for studying the effects of tetrahydrobiopterin on monoamine neurotransmitters in rat striatum",

abstract = " Tetrahydrobiopterin (BH 4 ) is an essential co-factor in the biosynthesis of monoamine neurotransmitters. A nano-Pt/Pd modified electrode as the electrochemical detector (ED) for high-performance liquid chromatography (HPLC) coupled with microanalysis sampling, is used to explore the effect of administration of BH 4 on the monoamine neurotransmitters in the rat striatum. The researches demonstrate that the contents of dopamine (DA), 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) increase significantly with the administration of BH 4 . The pharmaceutical kinetics is carried out to research into the time course of BH 4 effect on the concentration of monoamine neurotransmitters in rat striatum, which provides reliable data for pathology and pharmacology research on neuroscience. ",

keywords = "BH, ED, HPLC, Microanalysis sampling, Monoamine neurotransmitter, Nano-Pt/Pd modified electrode",

author = "Wen Zhang and Wei Zhu and Haihong Xu and Fangli Wan and Jing Gu and Jingen Han and Litong Jin",

year = "2005",

month = aug,

doi = "10.1360/04yb0133",

language = "英语",

volume = "48",

pages = "368--375",

journal = "Science in China, Series B: Chemistry",

issn = "1006-9291",

publisher = "Gordon and Breach Science Publishers",

number = "4",

}

TY - JOUR

T1 - Liquid chromatography-electrochemical detection for studying the effects of tetrahydrobiopterin on monoamine neurotransmitters in rat striatum

AU - Zhang, Wen

AU - Zhu, Wei

AU - Xu, Haihong

AU - Wan, Fangli

AU - Gu, Jing

AU - Han, Jingen

AU - Jin, Litong

PY - 2005/8

Y1 - 2005/8

N2 - Tetrahydrobiopterin (BH 4 ) is an essential co-factor in the biosynthesis of monoamine neurotransmitters. A nano-Pt/Pd modified electrode as the electrochemical detector (ED) for high-performance liquid chromatography (HPLC) coupled with microanalysis sampling, is used to explore the effect of administration of BH 4 on the monoamine neurotransmitters in the rat striatum. The researches demonstrate that the contents of dopamine (DA), 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) increase significantly with the administration of BH 4 . The pharmaceutical kinetics is carried out to research into the time course of BH 4 effect on the concentration of monoamine neurotransmitters in rat striatum, which provides reliable data for pathology and pharmacology research on neuroscience.

AB - Tetrahydrobiopterin (BH 4 ) is an essential co-factor in the biosynthesis of monoamine neurotransmitters. A nano-Pt/Pd modified electrode as the electrochemical detector (ED) for high-performance liquid chromatography (HPLC) coupled with microanalysis sampling, is used to explore the effect of administration of BH 4 on the monoamine neurotransmitters in the rat striatum. The researches demonstrate that the contents of dopamine (DA), 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) increase significantly with the administration of BH 4 . The pharmaceutical kinetics is carried out to research into the time course of BH 4 effect on the concentration of monoamine neurotransmitters in rat striatum, which provides reliable data for pathology and pharmacology research on neuroscience.

KW - BH

KW - ED

KW - HPLC

KW - Microanalysis sampling

KW - Monoamine neurotransmitter

KW - Nano-Pt/Pd modified electrode

UR - https://www.scopus.com/pages/publications/23744445589

U2 - 10.1360/04yb0133

DO - 10.1360/04yb0133

M3 - 文章

AN - SCOPUS:23744445589

SN - 1006-9291

VL - 48

SP - 368

EP - 375

JO - Science in China, Series B: Chemistry

JF - Science in China, Series B: Chemistry

IS - 4

ER -

Liquid chromatography-electrochemical detection for studying the effects of tetrahydrobiopterin on monoamine neurotransmitters in rat striatum

Abstract

Keywords

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