Ligand-free iridium-catalyzed regioselective C-H borylation of indoles

Zilong Pan; Luhua Liu; Senmiao Xu; Zhenlu Shen

doi:10.1039/d0ra10211c

Ligand-free iridium-catalyzed regioselective C-H borylation of indoles

Zilong Pan
, Luhua Liu
, Senmiao Xu^*
, Zhenlu Shen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We herein report a ligand-free Ir-catalyzed C-H borylation ofN-acyl protected indoles. This simple protocol could tolerate a variety of functional groups, affording C3 borylated indoles in good yields with excellent regioselectivities. We also demonstrated that the current method is amenable to gram-scale borylation and the C-B bonds could be easily converted to C-C and C-heteroatom bonds.

Original language	English
Pages (from-to)	5487-5490
Number of pages	4
Journal	RSC Advances
Volume	11
Issue number	10
DOIs	https://doi.org/10.1039/d0ra10211c
State	Published - 29 Jan 2021
Externally published	Yes

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title = "Ligand-free iridium-catalyzed regioselective C-H borylation of indoles",

abstract = "We herein report a ligand-free Ir-catalyzed C-H borylation ofN-acyl protected indoles. This simple protocol could tolerate a variety of functional groups, affording C3 borylated indoles in good yields with excellent regioselectivities. We also demonstrated that the current method is amenable to gram-scale borylation and the C-B bonds could be easily converted to C-C and C-heteroatom bonds.",

author = "Zilong Pan and Luhua Liu and Senmiao Xu and Zhenlu Shen",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",

year = "2021",

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doi = "10.1039/d0ra10211c",

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T1 - Ligand-free iridium-catalyzed regioselective C-H borylation of indoles

AU - Pan, Zilong

AU - Liu, Luhua

AU - Xu, Senmiao

AU - Shen, Zhenlu

PY - 2021/1/29

Y1 - 2021/1/29

N2 - We herein report a ligand-free Ir-catalyzed C-H borylation ofN-acyl protected indoles. This simple protocol could tolerate a variety of functional groups, affording C3 borylated indoles in good yields with excellent regioselectivities. We also demonstrated that the current method is amenable to gram-scale borylation and the C-B bonds could be easily converted to C-C and C-heteroatom bonds.

AB - We herein report a ligand-free Ir-catalyzed C-H borylation ofN-acyl protected indoles. This simple protocol could tolerate a variety of functional groups, affording C3 borylated indoles in good yields with excellent regioselectivities. We also demonstrated that the current method is amenable to gram-scale borylation and the C-B bonds could be easily converted to C-C and C-heteroatom bonds.

UR - https://www.scopus.com/pages/publications/85100515368

U2 - 10.1039/d0ra10211c

DO - 10.1039/d0ra10211c

M3 - 文章

AN - SCOPUS:85100515368

SN - 2046-2069

VL - 11

SP - 5487

EP - 5490

JO - RSC Advances

JF - RSC Advances

IS - 10

ER -

Ligand-free iridium-catalyzed regioselective C-H borylation of indoles

Abstract

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