Ligand-Free Iridium-Catalyzed Dehydrogenative ortho C−H Borylation of Benzyl-2-Pyridines at Room Temperature

Yuhuan Yang; Qian Gao; Senmiao Xu

doi:10.1002/adsc.201801292

Ligand-Free Iridium-Catalyzed Dehydrogenative ortho C−H Borylation of Benzyl-2-Pyridines at Room Temperature

Yuhuan Yang
, Qian Gao
, Senmiao Xu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A convenient and ligand-free iridium-catalyzed dehydrogenative ortho C−H borylation of benzyl-2-pyridines has been developed. The reaction proceeds smoothly at room temperature using pinacolborane as a borylating reagent in the presence of catalytic amount of [IrOMe(COD)] ₂ . The reaction is compatible with many functional groups, providing a vast array of ortho borylated products in moderate to excellent yields with excellent selectivities. (Figure presented.).

Original language	English
Pages (from-to)	858-862
Number of pages	5
Journal	Advanced Synthesis and Catalysis
Volume	361
Issue number	4
DOIs	https://doi.org/10.1002/adsc.201801292
State	Published - 19 Feb 2019
Externally published	Yes

Keywords

C−H activation
borylation
iridium
organoboron
synthetic methods

Access to Document

10.1002/adsc.201801292

Cite this

@article{75e270bb09b545fa9fef74aa62dc6bae,

title = "Ligand-Free Iridium-Catalyzed Dehydrogenative ortho C−H Borylation of Benzyl-2-Pyridines at Room Temperature",

abstract = " A convenient and ligand-free iridium-catalyzed dehydrogenative ortho C−H borylation of benzyl-2-pyridines has been developed. The reaction proceeds smoothly at room temperature using pinacolborane as a borylating reagent in the presence of catalytic amount of [IrOMe(COD)] 2 . The reaction is compatible with many functional groups, providing a vast array of ortho borylated products in moderate to excellent yields with excellent selectivities. (Figure presented.).",

keywords = "C−H activation, borylation, iridium, organoboron, synthetic methods",

author = "Yuhuan Yang and Qian Gao and Senmiao Xu",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim",

year = "2019",

month = feb,

day = "19",

doi = "10.1002/adsc.201801292",

language = "英语",

volume = "361",

pages = "858--862",

journal = "Advanced Synthesis and Catalysis",

issn = "1615-4150",

publisher = "Wiley-VCH Verlag",

number = "4",

}

TY - JOUR

T1 - Ligand-Free Iridium-Catalyzed Dehydrogenative ortho C−H Borylation of Benzyl-2-Pyridines at Room Temperature

AU - Yang, Yuhuan

AU - Gao, Qian

AU - Xu, Senmiao

PY - 2019/2/19

Y1 - 2019/2/19

N2 - A convenient and ligand-free iridium-catalyzed dehydrogenative ortho C−H borylation of benzyl-2-pyridines has been developed. The reaction proceeds smoothly at room temperature using pinacolborane as a borylating reagent in the presence of catalytic amount of [IrOMe(COD)] 2 . The reaction is compatible with many functional groups, providing a vast array of ortho borylated products in moderate to excellent yields with excellent selectivities. (Figure presented.).

AB - A convenient and ligand-free iridium-catalyzed dehydrogenative ortho C−H borylation of benzyl-2-pyridines has been developed. The reaction proceeds smoothly at room temperature using pinacolborane as a borylating reagent in the presence of catalytic amount of [IrOMe(COD)] 2 . The reaction is compatible with many functional groups, providing a vast array of ortho borylated products in moderate to excellent yields with excellent selectivities. (Figure presented.).

KW - C−H activation

KW - borylation

KW - iridium

KW - organoboron

KW - synthetic methods

UR - https://www.scopus.com/pages/publications/85058952285

U2 - 10.1002/adsc.201801292

DO - 10.1002/adsc.201801292

M3 - 文章

AN - SCOPUS:85058952285

SN - 1615-4150

VL - 361

SP - 858

EP - 862

JO - Advanced Synthesis and Catalysis

JF - Advanced Synthesis and Catalysis

IS - 4

ER -

Ligand-Free Iridium-Catalyzed Dehydrogenative ortho C−H Borylation of Benzyl-2-Pyridines at Room Temperature

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this