Lgr4 Protein deficiency induces ataxia-like phenotype in mice and impairs long term depression at cerebellar Parallel fiber-purkinje cell synapses

Background: Cerebellar dysfunction leads to ataxia characterized by loss of balance and coordination.

Results: Lgr4 deficiency mice show an ataxia-like phenotype and impaired long term depression in cerebellum.

Conclusion: Lgr4-mediated cAMP-Creb signaling is required for motor coordination and cerebellar synaptic plasticity.

Significance: Lgr4 has potential implications for diagnosis or drug discovery of inherited cerebellar ataxia.