Lewis acid-catalyzed cyclization of enaminones with propargylic alcohols: Regioselective synthesis of multisubstituted 1,2-dihydropyridines

Yushang Shao; Kai Zhu; Zhengchen Qin; Ende Li; Yanzhong Li

doi:10.1021/jo4005553

Lewis acid-catalyzed cyclization of enaminones with propargylic alcohols: Regioselective synthesis of multisubstituted 1,2-dihydropyridines

Yushang Shao
, Kai Zhu
, Zhengchen Qin
, Ende Li
, Yanzhong Li^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

A highly efficient BF₃·Et₂O-catalyzed cascade reaction of enaminones with propargylic alcohols under mild reaction conditions has been developed. This methodology offers regioselective access to multisubstituted 1,2-dihydropyridines in good to excellent yields.

Original language	English
Pages (from-to)	5731-5736
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	78
Issue number	11
DOIs	https://doi.org/10.1021/jo4005553
State	Published - 7 Jun 2013

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title = "Lewis acid-catalyzed cyclization of enaminones with propargylic alcohols: Regioselective synthesis of multisubstituted 1,2-dihydropyridines",

abstract = "A highly efficient BF3·Et2O-catalyzed cascade reaction of enaminones with propargylic alcohols under mild reaction conditions has been developed. This methodology offers regioselective access to multisubstituted 1,2-dihydropyridines in good to excellent yields.",

author = "Yushang Shao and Kai Zhu and Zhengchen Qin and Ende Li and Yanzhong Li",

year = "2013",

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issn = "0022-3263",

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T1 - Lewis acid-catalyzed cyclization of enaminones with propargylic alcohols

T2 - Regioselective synthesis of multisubstituted 1,2-dihydropyridines

AU - Shao, Yushang

AU - Zhu, Kai

AU - Qin, Zhengchen

AU - Li, Ende

AU - Li, Yanzhong

PY - 2013/6/7

Y1 - 2013/6/7

N2 - A highly efficient BF3·Et2O-catalyzed cascade reaction of enaminones with propargylic alcohols under mild reaction conditions has been developed. This methodology offers regioselective access to multisubstituted 1,2-dihydropyridines in good to excellent yields.

AB - A highly efficient BF3·Et2O-catalyzed cascade reaction of enaminones with propargylic alcohols under mild reaction conditions has been developed. This methodology offers regioselective access to multisubstituted 1,2-dihydropyridines in good to excellent yields.

UR - https://www.scopus.com/pages/publications/84879303896

U2 - 10.1021/jo4005553

DO - 10.1021/jo4005553

M3 - 文章

C2 - 23651059

AN - SCOPUS:84879303896

SN - 0022-3263

VL - 78

SP - 5731

EP - 5736

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 11

ER -

Lewis acid-catalyzed cyclization of enaminones with propargylic alcohols: Regioselective synthesis of multisubstituted 1,2-dihydropyridines

Abstract

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