LDA-Promoted Synthesis of 3-Amino Furans by Selective Lithiation of Enaminones

Lingkai Kong; Yushang Shao; Yanli Li; Yuanyuan Liu; Yanzhong Li

doi:10.1021/acs.joc.5b02211

LDA-Promoted Synthesis of 3-Amino Furans by Selective Lithiation of Enaminones

Lingkai Kong
, Yushang Shao
, Yanli Li
, Yuanyuan Liu^*
, Yanzhong Li

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

An efficient cascade β-metalation/addition/cyclization reaction promoted by LDA is described in which 3-amino furans were constructed from enaminones and aldehydes. A broad range of substituents on the starting compounds was tolerated, and the polysubstituted furans were gained with moderate to excellent yields within 2 h.

Original language	English
Pages (from-to)	12641-12645
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	80
Issue number	24
DOIs	https://doi.org/10.1021/acs.joc.5b02211
State	Published - 18 Nov 2015

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title = "LDA-Promoted Synthesis of 3-Amino Furans by Selective Lithiation of Enaminones",

abstract = "An efficient cascade β-metalation/addition/cyclization reaction promoted by LDA is described in which 3-amino furans were constructed from enaminones and aldehydes. A broad range of substituents on the starting compounds was tolerated, and the polysubstituted furans were gained with moderate to excellent yields within 2 h.",

author = "Lingkai Kong and Yushang Shao and Yanli Li and Yuanyuan Liu and Yanzhong Li",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = nov,

day = "18",

doi = "10.1021/acs.joc.5b02211",

language = "英语",

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journal = "Journal of Organic Chemistry",

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T1 - LDA-Promoted Synthesis of 3-Amino Furans by Selective Lithiation of Enaminones

AU - Kong, Lingkai

AU - Shao, Yushang

AU - Li, Yanli

AU - Liu, Yuanyuan

AU - Li, Yanzhong

PY - 2015/11/18

Y1 - 2015/11/18

N2 - An efficient cascade β-metalation/addition/cyclization reaction promoted by LDA is described in which 3-amino furans were constructed from enaminones and aldehydes. A broad range of substituents on the starting compounds was tolerated, and the polysubstituted furans were gained with moderate to excellent yields within 2 h.

AB - An efficient cascade β-metalation/addition/cyclization reaction promoted by LDA is described in which 3-amino furans were constructed from enaminones and aldehydes. A broad range of substituents on the starting compounds was tolerated, and the polysubstituted furans were gained with moderate to excellent yields within 2 h.

UR - https://www.scopus.com/pages/publications/84952815474

U2 - 10.1021/acs.joc.5b02211

DO - 10.1021/acs.joc.5b02211

M3 - 文章

AN - SCOPUS:84952815474

SN - 0022-3263

VL - 80

SP - 12641

EP - 12645

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 24

ER -

LDA-Promoted Synthesis of 3-Amino Furans by Selective Lithiation of Enaminones

Abstract

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