TY - JOUR
T1 - LC with novel electrochemical detection for analysis of monoamine neurotransmitters in rat brain after administration of (R)-salsolinol and (R)-N-methylsalsolinol
AU - Wang, Dan
AU - Zhu, Wei
AU - An, Yarui
AU - Zheng, Jiaohong
AU - Zhang, Wen
AU - Jin, Litong
AU - Gao, Hongying
AU - Lin, Longnian
PY - 2008/3
Y1 - 2008/3
N2 - A novel electrochemical detector with an acetylcholine film has been developed for HPLC. The chemically modified electrode is an efficient electrocatalyst of (R)-salsolinol ((R)-Sal), (R)-N-methylsalsolinol ((R)-NMSal), and monoamine neurotransmitters, enabling highly sensitive detection. The electrode is also stable and long-lived. Combined with microdialysis sampling, HPLC with the novel detector enabled successful study of changes in the concentrations of monoamine neurotransmitters in rat brain after the injection of (R)-salsolinol and (R)-N-methylsalsolinol.
AB - A novel electrochemical detector with an acetylcholine film has been developed for HPLC. The chemically modified electrode is an efficient electrocatalyst of (R)-salsolinol ((R)-Sal), (R)-N-methylsalsolinol ((R)-NMSal), and monoamine neurotransmitters, enabling highly sensitive detection. The electrode is also stable and long-lived. Combined with microdialysis sampling, HPLC with the novel detector enabled successful study of changes in the concentrations of monoamine neurotransmitters in rat brain after the injection of (R)-salsolinol and (R)-N-methylsalsolinol.
KW - (R)-N-methylsalsolinol
KW - (R)-Salsolinol
KW - Acetylcholine chemically modified electrode
KW - Column liquid chromatography
KW - Electrochemical detection
KW - Monoamine neurotransmitters
UR - https://www.scopus.com/pages/publications/40149088268
U2 - 10.1365/s10337-008-0532-7
DO - 10.1365/s10337-008-0532-7
M3 - 文章
AN - SCOPUS:40149088268
SN - 0009-5893
VL - 67
SP - 369
EP - 374
JO - Chromatographia
JF - Chromatographia
IS - 5-6
ER -