Large-pore ultrasmall mesoporous organosilica nanoparticles: Micelle/precursor co-templating assembly and nuclear-targeted gene delivery

Meiying Wu; Qingshuo Meng; Yu Chen; Yanyan Du; Lingxia Zhang; Yaping Li; Linlin Zhang; Jianlin Shi

doi:10.1002/adma.201404256

Large-pore ultrasmall mesoporous organosilica nanoparticles: Micelle/precursor co-templating assembly and nuclear-targeted gene delivery

Meiying Wu
, Qingshuo Meng
, Yu Chen^*
, Yanyan Du
, Lingxia Zhang
, Yaping Li
, Linlin Zhang
, Jianlin Shi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

283 Scopus citations

Abstract

(Figure Presented) A novel micelle/precursor co-templating assembly strategy is successfully developed to synthesize large-pore ultrasmall mesoporous organosilica nanoparticles (MONs). Furthermore, elaborately designed MONs with a cell-penetrating peptide (TAT) (MONs-PTAT) are constructed for highly efficient intranuclear gene delivery. They exhibit a high loading capacity, improved protection for the loaded gene, and enhanced transfection efficiencies of EGFP plasmid (pEGFP).

Original language	English
Pages (from-to)	215-222
Number of pages	8
Journal	Advanced Materials
Volume	27
Issue number	2
DOIs	https://doi.org/10.1002/adma.201404256
State	Published - 14 Jan 2015
Externally published	Yes

Keywords

Gene delivery
Large mesopores
Mesoporous organosilicas
Nuclear-targeted

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10.1002/adma.201404256

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title = "Large-pore ultrasmall mesoporous organosilica nanoparticles: Micelle/precursor co-templating assembly and nuclear-targeted gene delivery",

abstract = "(Figure Presented) A novel micelle/precursor co-templating assembly strategy is successfully developed to synthesize large-pore ultrasmall mesoporous organosilica nanoparticles (MONs). Furthermore, elaborately designed MONs with a cell-penetrating peptide (TAT) (MONs-PTAT) are constructed for highly efficient intranuclear gene delivery. They exhibit a high loading capacity, improved protection for the loaded gene, and enhanced transfection efficiencies of EGFP plasmid (pEGFP).",

keywords = "Gene delivery, Large mesopores, Mesoporous organosilicas, Nuclear-targeted",

author = "Meiying Wu and Qingshuo Meng and Yu Chen and Yanyan Du and Lingxia Zhang and Yaping Li and Linlin Zhang and Jianlin Shi",

note = "Publisher Copyright: {\textcopyright} 2014 Wiley-VCH Verlag GmbH \& Co. KGaA.",

year = "2015",

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day = "14",

doi = "10.1002/adma.201404256",

language = "英语",

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journal = "Advanced Materials",

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T1 - Large-pore ultrasmall mesoporous organosilica nanoparticles

T2 - Micelle/precursor co-templating assembly and nuclear-targeted gene delivery

AU - Wu, Meiying

AU - Meng, Qingshuo

AU - Chen, Yu

AU - Du, Yanyan

AU - Zhang, Lingxia

AU - Li, Yaping

AU - Zhang, Linlin

AU - Shi, Jianlin

PY - 2015/1/14

Y1 - 2015/1/14

N2 - (Figure Presented) A novel micelle/precursor co-templating assembly strategy is successfully developed to synthesize large-pore ultrasmall mesoporous organosilica nanoparticles (MONs). Furthermore, elaborately designed MONs with a cell-penetrating peptide (TAT) (MONs-PTAT) are constructed for highly efficient intranuclear gene delivery. They exhibit a high loading capacity, improved protection for the loaded gene, and enhanced transfection efficiencies of EGFP plasmid (pEGFP).

AB - (Figure Presented) A novel micelle/precursor co-templating assembly strategy is successfully developed to synthesize large-pore ultrasmall mesoporous organosilica nanoparticles (MONs). Furthermore, elaborately designed MONs with a cell-penetrating peptide (TAT) (MONs-PTAT) are constructed for highly efficient intranuclear gene delivery. They exhibit a high loading capacity, improved protection for the loaded gene, and enhanced transfection efficiencies of EGFP plasmid (pEGFP).

KW - Gene delivery

KW - Large mesopores

KW - Mesoporous organosilicas

KW - Nuclear-targeted

UR - https://www.scopus.com/pages/publications/84920725496

U2 - 10.1002/adma.201404256

DO - 10.1002/adma.201404256

M3 - 文章

C2 - 25423915

AN - SCOPUS:84920725496

SN - 0935-9648

VL - 27

SP - 215

EP - 222

JO - Advanced Materials

JF - Advanced Materials

IS - 2

ER -

Large-pore ultrasmall mesoporous organosilica nanoparticles: Micelle/precursor co-templating assembly and nuclear-targeted gene delivery

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Keywords

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