Large-conductance calcium-activated potassium channels in glomerulus: From cell signal integration to disease

Jie Tao; Zhen Lan; Yunman Wang; Hongya Hei; Lulu Tian; Wanma Pan; Xuemei Zhang; Wen Peng

doi:10.3389/fphys.2016.00248

Large-conductance calcium-activated potassium channels in glomerulus: From cell signal integration to disease

Jie Tao
, Zhen Lan
, Yunman Wang
, Hongya Hei
, Lulu Tian
, Wanma Pan
, Xuemei Zhang^*
, Wen Peng

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca²⁺, possibly secondary to activation of slit diaphragm TRPC6 channels by chemical or mechanical stimuli. Insulin increases filtration barrier permeability through mobilization of BK channels. In mesangial cells, BK channels co-expressed with β1 subunits act as a major component of the counteractive response to contraction in order to regulate glomerular filtration. This review aims to highlight recent discoveries on the localization, physiological and pathological roles of BK channels in glomerulus.

Original language	English
Article number	248
Journal	Frontiers in Physiology
Volume	7
Issue number	JUN
DOIs	https://doi.org/10.3389/fphys.2016.00248
State	Published - 21 Jun 2016
Externally published	Yes

Keywords

BK channels
Glomerular filtration
Mesangial cells
Podocytes
β subunits

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10.3389/fphys.2016.00248

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title = "Large-conductance calcium-activated potassium channels in glomerulus: From cell signal integration to disease",

abstract = "Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca2+, possibly secondary to activation of slit diaphragm TRPC6 channels by chemical or mechanical stimuli. Insulin increases filtration barrier permeability through mobilization of BK channels. In mesangial cells, BK channels co-expressed with β1 subunits act as a major component of the counteractive response to contraction in order to regulate glomerular filtration. This review aims to highlight recent discoveries on the localization, physiological and pathological roles of BK channels in glomerulus.",

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author = "Jie Tao and Zhen Lan and Yunman Wang and Hongya Hei and Lulu Tian and Wanma Pan and Xuemei Zhang and Wen Peng",

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T1 - Large-conductance calcium-activated potassium channels in glomerulus

T2 - From cell signal integration to disease

AU - Tao, Jie

AU - Lan, Zhen

AU - Wang, Yunman

AU - Hei, Hongya

AU - Tian, Lulu

AU - Pan, Wanma

AU - Zhang, Xuemei

AU - Peng, Wen

PY - 2016/6/21

Y1 - 2016/6/21

N2 - Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca2+, possibly secondary to activation of slit diaphragm TRPC6 channels by chemical or mechanical stimuli. Insulin increases filtration barrier permeability through mobilization of BK channels. In mesangial cells, BK channels co-expressed with β1 subunits act as a major component of the counteractive response to contraction in order to regulate glomerular filtration. This review aims to highlight recent discoveries on the localization, physiological and pathological roles of BK channels in glomerulus.

AB - Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca2+, possibly secondary to activation of slit diaphragm TRPC6 channels by chemical or mechanical stimuli. Insulin increases filtration barrier permeability through mobilization of BK channels. In mesangial cells, BK channels co-expressed with β1 subunits act as a major component of the counteractive response to contraction in order to regulate glomerular filtration. This review aims to highlight recent discoveries on the localization, physiological and pathological roles of BK channels in glomerulus.

KW - BK channels

KW - Glomerular filtration

KW - Mesangial cells

KW - Podocytes

KW - β subunits

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DO - 10.3389/fphys.2016.00248

M3 - 短篇评述

AN - SCOPUS:84977659035

SN - 1664-042X

VL - 7

JO - Frontiers in Physiology

JF - Frontiers in Physiology

IS - JUN

M1 - 248

ER -

Large-conductance calcium-activated potassium channels in glomerulus: From cell signal integration to disease

Abstract

Keywords

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