Label-free DNA detection based on silicon nanowires

A. R. Gao; N. Lu; X. L. Gao; P. F. Dai; T. Li; Y. B. Gong; C. H. Fan; Y. L. Wang

doi:10.1109/TRANSDUCERS.2011.5969329

Label-free DNA detection based on silicon nanowires

A. R. Gao
, N. Lu
, X. L. Gao
, P. F. Dai
, T. Li^*
, Y. B. Gong
, C. H. Fan
, Y. L. Wang

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

Based on silicon nanowires (SiNWs) fabricated by MEMS technology, highly sensitive, sequence-specific and label-free DNA sensors were demonstrated in this paper. Optical lithography and anisotropic self-stop etching were employed to guarantee low cost batch production for SiNWs. Amine-functionalized SiNWs exhibit pH-dependent linear current over a wide range. SiNWs with chemically functionalized single-stranded DNA can recognize the complementary DNA at pM range. In contrast, there is no current change for non-complementary DNA even at a high concentration. With small size and potential for mass production, SiNWs can be potentially developed to become a portable biosensor.

Original language	English
Title of host publication	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Pages	2271-2274
Number of pages	4
DOIs	https://doi.org/10.1109/TRANSDUCERS.2011.5969329
State	Published - 2011
Externally published	Yes
Event	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 - Beijing, China Duration: 5 Jun 2011 → 9 Jun 2011

Publication series

Name	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11

Conference

Conference	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Country/Territory	China
City	Beijing
Period	5/06/11 → 9/06/11

Keywords

DNA
FET
SiNWs
label-free

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10.1109/TRANSDUCERS.2011.5969329

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Gao, A. R., Lu, N., Gao, X. L., Dai, P. F., Li, T., Gong, Y. B., Fan, C. H., & Wang, Y. L. (2011). Label-free DNA detection based on silicon nanowires. In 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 (pp. 2271-2274). Article 5969329 (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11). https://doi.org/10.1109/TRANSDUCERS.2011.5969329

@inproceedings{ccaead010996415aba8a7d7cc4aad4f9,

title = "Label-free DNA detection based on silicon nanowires",

abstract = "Based on silicon nanowires (SiNWs) fabricated by MEMS technology, highly sensitive, sequence-specific and label-free DNA sensors were demonstrated in this paper. Optical lithography and anisotropic self-stop etching were employed to guarantee low cost batch production for SiNWs. Amine-functionalized SiNWs exhibit pH-dependent linear current over a wide range. SiNWs with chemically functionalized single-stranded DNA can recognize the complementary DNA at pM range. In contrast, there is no current change for non-complementary DNA even at a high concentration. With small size and potential for mass production, SiNWs can be potentially developed to become a portable biosensor.",

keywords = "DNA, FET, SiNWs, label-free",

author = "Gao, \{A. R.\} and N. Lu and Gao, \{X. L.\} and Dai, \{P. F.\} and T. Li and Gong, \{Y. B.\} and Fan, \{C. H.\} and Wang, \{Y. L.\}",

year = "2011",

doi = "10.1109/TRANSDUCERS.2011.5969329",

language = "英语",

isbn = "9781457701573",

series = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11",

pages = "2271--2274",

booktitle = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11",

note = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 ; Conference date: 05-06-2011 Through 09-06-2011",

}

Gao, AR, Lu, N, Gao, XL, Dai, PF, Li, T, Gong, YB, Fan, CH & Wang, YL 2011, Label-free DNA detection based on silicon nanowires. in 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11., 5969329, 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11, pp. 2271-2274, 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11, Beijing, China, 5/06/11. https://doi.org/10.1109/TRANSDUCERS.2011.5969329

Label-free DNA detection based on silicon nanowires. / Gao, A. R.; Lu, N.; Gao, X. L. et al.
2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11. 2011. p. 2271-2274 5969329 (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Label-free DNA detection based on silicon nanowires

AU - Gao, A. R.

AU - Lu, N.

AU - Gao, X. L.

AU - Dai, P. F.

AU - Li, T.

AU - Gong, Y. B.

AU - Fan, C. H.

AU - Wang, Y. L.

PY - 2011

Y1 - 2011

N2 - Based on silicon nanowires (SiNWs) fabricated by MEMS technology, highly sensitive, sequence-specific and label-free DNA sensors were demonstrated in this paper. Optical lithography and anisotropic self-stop etching were employed to guarantee low cost batch production for SiNWs. Amine-functionalized SiNWs exhibit pH-dependent linear current over a wide range. SiNWs with chemically functionalized single-stranded DNA can recognize the complementary DNA at pM range. In contrast, there is no current change for non-complementary DNA even at a high concentration. With small size and potential for mass production, SiNWs can be potentially developed to become a portable biosensor.

AB - Based on silicon nanowires (SiNWs) fabricated by MEMS technology, highly sensitive, sequence-specific and label-free DNA sensors were demonstrated in this paper. Optical lithography and anisotropic self-stop etching were employed to guarantee low cost batch production for SiNWs. Amine-functionalized SiNWs exhibit pH-dependent linear current over a wide range. SiNWs with chemically functionalized single-stranded DNA can recognize the complementary DNA at pM range. In contrast, there is no current change for non-complementary DNA even at a high concentration. With small size and potential for mass production, SiNWs can be potentially developed to become a portable biosensor.

KW - DNA

KW - FET

KW - SiNWs

KW - label-free

UR - https://www.scopus.com/pages/publications/80052126217

U2 - 10.1109/TRANSDUCERS.2011.5969329

DO - 10.1109/TRANSDUCERS.2011.5969329

M3 - 会议稿件

AN - SCOPUS:80052126217

SN - 9781457701573

T3 - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11

SP - 2271

EP - 2274

BT - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11

T2 - 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11

Y2 - 5 June 2011 through 9 June 2011

ER -

Gao AR, Lu N, Gao XL, Dai PF, Li T, Gong YB et al. Label-free DNA detection based on silicon nanowires. In 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11. 2011. p. 2271-2274. 5969329. (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11). doi: 10.1109/TRANSDUCERS.2011.5969329

Label-free DNA detection based on silicon nanowires

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